Table 3.
Comparisons of effusion biomarker concentrations in dogs with septic peritonitis (SP) and non-septic peritonitis (NSA).
| Effusion | ||||
|---|---|---|---|---|
| SP median IQR | NSA median IQR | P-value | Pcorr | |
| Glucose (mg/dL) | 20 | 94 | 0.011 | 0.121 |
| 20–108 | 78–99 | |||
| Glucose (mmol/L) | 1.1 | 5.2 | 0.011 | 0.121 |
| 1.1–6.0 | 4.3–5.5 | |||
| Lactate (mmol/L) | 7.9 | 1.8 | 0.0001 | 0.0011 |
| 2.7–11.3 | 1.1–2.8 | |||
| cfDNA (ng/mL) | 1085 | 470 | 0.0205 | 0.2255 |
| 493–2723 | 269–1157 | |||
| Nucleosomes (AU) | 13.1 | 2.5 | 0.0056 | 0.0616 |
| 4.4–25.1 | 0.3–12.9 | |||
| NT-proCNP (pmol/L) | 6.2 | 2.3 | 0.2806 | 3.0866 |
| 1.9–25.7 | 1.6–10.3 | |||
| PCT (pg/mL) | 38.4 | 98.9 | 0.0489 | 0.5379 |
| 0–119.2 | 29.7–201.6 | |||
| CCL2 (pg/mL) | 16066 | 683 | 0.0011 | 0.0121 |
| 2508–96300 | 449–2225 | |||
| CXCL8 (pg/mL) | 4325.0 | 129.6 | 0.0113 | 0.1243 |
| 21.7–75000.0 | 21.7–444.7 | |||
| IL-10 (pg/mL) | 303.1 | 8.5 | 0.0001 | 0.0011 |
| 147.6–1584.0 | 8.5–31.9 | |||
| IL-6 (pg/mL) | 2775.0 | 37.9 | 0.0011 | 0.0121 |
| 363.5–11495.0 | 3.7–1918.0 | |||
| KC-Like (pg/mL) | 1215.0 | 456.2 | 0.312 | 3.432 |
| 37.2–6973.0 | 62.1–757.0 | |||
Median and IQR concentrations of measured biomarkers in effusion in patients with SP and NSA, and results of univariate comparisons of biomarker concentrations between groups by Mann-Whitney U-test. Biomarkers identified to be significantly different in effusion compared between SP and NSA groups after correction for multiple comparisons (P <0.05) are indicated in bold typeface. AU, arbitrary unit; CCL2, C-C Motif Chemokine Ligand-2; cfDNA, cell-free DNA; CXCL8, chemokine C-X-C motif ligand 8; IL, interleukin; IQR, interquartile range; KC-Like, keratinocyte chemoattractant-like; NSA, non-septic ascites; NT-proCNP, amino-terminal propeptide of C-type natriuretic peptide; Pcorr, P value corrected for multiple comparisons; PCT, procalcitonin; SP, septic peritonitis.