Table 4.

Comparisons of blood-effusion biomarker concentration gradients in dogs with septic peritonitis (SP) and non-septic peritonitis (NSA).

	Blood-Effusion Gradient
	SP median IQR	NSA median IQR	P-value	Pcorr
Glucose (mg/dL)	59	6	0.0009	0.0099
	16–91	−6–27
Glucose (mmol/L)	3.3	0.3	0.0009	0.0099
	0.9–5.1	−0.3–1.5
Lactate (mmol/L)	−4.9	0.2	0.0015	0.0165
	−8.5 to −0.5	−0.9–0.6
cfDNA (ng/mL)	−757	−31	0.005	0.055
	−2331 to −179	−527–165
Nucleosomes (AU)	−13.0	−0.7	0.0066	0.0726
	−22.5 to −3.4	−12.8–0.3
NT-proCNP (pmol/L)	2.4	0.8	0.3744	4.1624
	−1.6–7.4	−0.5–2.6
PCT (pg/mL)	27.9	22.4	0.0861	0.9471
	8.3–98.7	−32.7–33.7
CCL2 (pg/mL)	−14151	−561	0.0006	0.0066
	−91817 to −2243	−1827 to −110
CXCL8 (pg/mL)	−3657.0	134.1	0.0129	0.1419
	−68631.0–623.7	−51.1–1316.0
IL-10 (pg/mL)	−294.6	0.0	0.0004	0.0044
	−1430.0 to −63.8	−23.4 to 0.0
IL-6 (pg/mL)	−2772.0	−0.5	0.0009	0.0099
	−10272.0 to −359.8	−1914.0 to 0.0
KC-Like (pg/mL)	−937.3	−425.5	0.3786	4.1646
	−4615.0 to −31.9	−716.7 to −41.3

Median and IQR blood-effusion concentration gradients of measured biomarkers in patients with SP and NSA, and results of univariate comparisons of biomarker concentration gradients between groups by Mann-Whitney U-test. Biomarker bloodeffusion gradients identified to be significantly different compared between SP and NSA groups after correction for multiple comparisons (P <0.05) are indicated in bold typeface. AU, arbitrary unit; CCL2, C-C Motif Chemokine Ligand-2; cfDNA, cell-free DNA; CXCL8, chemokine C-X-C motif ligand 8; IL, interleukin; IQR, interquartile range; KC-Like, keratinocyte chemoattractant-like; NSA, non-septic ascites; NT-proCNP, amino-terminal propeptide of C-type natriuretic peptide; P_corr, P value corrected formultiple comparisons; PCT, procalcitonin; SP, septic peritonitis.