Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 3;10:2040622319860653. doi: 10.1177/2040622319860653

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 8. — Schematic diagram of the effects and mechanisms of attenuating TDF-induced bone loss using LGG in mice.

LGG reconstructed the community structure of the gut microbiota and promoted the expression of preponderant metabolites (glycerophospholipids) to suppress TDF-induced N-acetyl LTE₄. LGG further improved the intestinal integrity and reversed the inflammatory response systemically, resulting in attenuation of TDF-induced bone loss in mice.

LGG, Lactobacillus rhamnosus GG; LTE₄, leukotriene E4; TDF, tenofovir disoproxil fumarate.