Table 2.
Differential metabolites identified from the OPLS-DA between the LGG+TDF and TDF groups (VIP > 1.0 and FC > 2.5 or < 0.4).
| No. | Metabolites | Category | VIP | FC (LGG+TDF/TDF) | p value |
|---|---|---|---|---|---|
| 1 | LysoPC [20:3(5Z,8Z,11Z)] | Glycerophospholipid | 1.661 | 6.768 | 0.020# |
| 2 | LysoPC [20:2(11Z,14Z)] | Glycerophospholipid | 1.003 | 3.689 | 0.009# |
| 3 | L-alpha-Amino-1H-pyrrole-1-hexanoic acid | Organic acid | 1.952 | 3.675 | 0.0002# |
| 4 | N-(heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide | Heterocyclic organic compounds | 1.782 | 3.590 | 0.007# |
| 5 | PE-NMe (11:0/11:0) | Glycerophospholipid | 1.458 | 3.374 | 0.008 # |
| 6 | PS (19:0/0:0) | Glycerophospholipid | 1.208 | 3.314 | 0.004# |
| 7 | N-oleoyl tyrosine | Amino acid | 4.343 | 3.152 | 0.014# |
| 8 | 15-HETE-VA | Fatty amide | 1.658 | 3.021 | 0.008# |
| 9 | 9S-(2-cyclopentenyl)-1-nonanol | Aliphatic alcohol | 2.201 | 3.021 | 0.001# |
| 10 | Lucidenic acid M | Triterpene | 1.525 | 2.953 | 0.047# |
| 11 | LysoPC [22:1(13Z)] | Glycerophospholipid | 4.607 | 2.680 | 0.001# |
| 12 | 4,5-Dihydropiperlonguminine | Heterocyclic organic compounds | 1.408 | 2.648 | 0.023# |
| 13 | Cer (d18:0/h17:0) | Sphingolipid | 1.717 | 2.576 | 0.035# |
| 14 | LysoPC [20:1(11Z)] | Glycerophospholipid | 1.001 | 2.549 | 0.006# |
| 15 | Reticulatamol | Aliphatic alcohol | 1.659 | 0.384 | 0.003# |
| 16 | PE [20:1(11Z)/P-18:1(11Z)] | Glycerophospholipid | 1.555 | 0.375 | 0.010# |
| 17 | PA [O-20:0/18:2(9Z,12Z)] | Glycerophospholipid | 1.525 | 0.370 | 0.018# |
| 18 | Isoleucyl-phenylalanine | Amino acid | 1.192 | 0.238 | 0.022# |
| 19 | N-acetyl-leukotriene E4 | Eicosanoid | 1.390 | 0.229 | 0.003# |
#
p < 0.05 compared with the LGG+TDF group.
FC, fold change; LGG, Lactobacillus rhamnosus GG; LysoPC, lysophosphatidylcholine; OPLS-DA, orthogonal partial least-squares-discriminant analysis; TDF, tenofovir disoproxil fumarate; VIP, variable importance in the projection.