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. 2019 Jun 27;13:673. doi: 10.3389/fnins.2019.00673

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Copyright © 2019 Amodio, Moltedo, Fasano, Zerillo, Oliveti, Di Pietro, Faraonio, Barone, Pellecchia, De Rosa, De Michele, Polishchuk, Polishchuk, Bonifati, Nitsch, Pierantoni, Renna, Criscuolo, Paladino and Remondelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The secretion of collagen IV is impaired in PARK20 fibroblasts. (A) HDF (WT) and PARK20 cells were seeded on glass coverslips, processed for immunofluorescence and analyzed by confocal imaging. Numbers on the right refers to Pearson’s correlation coefficient, quantified with Leica SP5 software (mean ± SD). p ≤ 0.01, Student’s t-test; N ≥ 30; scale bars: 10 μm. (B) Histogram shows the percent of collagen IV pixels colocalizing with KDEL pixels (mean ± SD) analyzed by Leica SP5 software. ^∗∗p ≤ 0.01, Student’s t-test.