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. 2019 Jun 27;10:1470. doi: 10.3389/fimmu.2019.01470

Figure 3.

Figure 3

HCV specific cytokine response in SVR and Relapse groups. (A) Gating strategy to identify live, single CD8+ T lymphocytes. (B) CD107a and TNFα detected by intracellular cytokine staining in unstimulated or HCV pooled peptide stimulated cultures in representative relapse and SVR sample. (C) Group mean values for fold change in HCV specific CD107a+ expression in CD8+ T cells calculated as ratio of CD107a+ CD8 T cells in HCV peptide stimulated to unstimulated wells at baseline (d0) and end of treatment (EOT) (D–G) Frequencies of HCV specific double or triple cytokine producing CD8+ T cells from SVR or relapse groups at baseline (d0) and end of treatment (EOT). Statistical significances determined by Wilcoxon matched paired test for within group, Mann Whitney test for between group comparisons, p ≤ 0.05 is significant. D0, baseline; wk4, EOT, Rel, relpase. *p ≤ 0.05, **p ≤ 0.01.