Table 2.
Screening Performance of Different CGM-Derived Parameters to Predict Severe Hypoglycemia or Persistence of Impaired Awareness of Hypoglycemia.
| CGM parameter | Area under ROC (95% CI) | Cutoff values | Sensitivity | Specificity |
|---|---|---|---|---|
| Prediction of severe hypoglycemia | ||||
| % <70 mg/dl (3.9 mmol/L) | 0.69 (0.54-0.85) | 7.0% | 71.4% | 66.6% |
| % <54 mg/dl (3.0 mmol/L) | 0.69 (0.52-0.85) | 2.4% | 71.4% | 59.6% |
| LBGI | 0,70 (0.55-0.86) | 1.6 | 71.4% | 57.7% |
| Number of <70 mg/dl (3.9 mmol/L) glucose events per 28 days | 0.72 (0.54-0.87) | 28 | 71.4% | 69.6% |
| Number of <54 mg/dl (3.0 mmol/L) glucose events per 28 days | 0.73 (0.55-0.86) | 10.5 | 71.4% | 59.6% |
| Number of prolonged <54 mg/dl (3.0 mmol/L) glucose events per 28 days | 0.69 (0.53-0.85) | 1 | 79.0% | 56.0% |
| Persistence of hypoglycemia unawareness | ||||
| % <70 mg/dl (3.9 mmol/L) | 0.78 (0.67-0.89) | 6.7% | 75.7% | 75.4% |
| % <54 mg/dl (3.0 mmol/L) | 0.79 (0.68-0.90) | 2.4% | 75.7% | 79.9% |
| LBGI | 0.79 (0.67-0.86 | 2.0 | 83.4% | 62.1% |
| Number of <70 mg/dl (3.9 mmol/L) glucose events per 28 days | 0.73 (0.60-0.85) | 31 | 75.7% | 62.1% |
| Number of <54 mg/dl (3.0 mmol/L) glucose events per 28 days | 0.79 (0.67-0.90) | 12.5 | 78.8% | 62.1% |
| Number of prolonged <54 mg/dl (3.0 mmol/L) glucose events per 28 days | 0.79 (0.68-0.90) | 1.5 | 73.0% | 83.0% |