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. 2019 Jul 3;9:9580. doi: 10.1038/s41598-019-45842-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Longer tissue disaggregation enables detection of more cell types, with concomitant increases in disaggregation-associated changes in gene expression. (a) Stacked barplot showing cell type fractions generated by disaggregation for 15 and 60 minutes. (b) Venn diagram showing overlap between murine disaggregation-associated signature⁵ (Murine DAG), human disaggregation-associated signature (Lung DAG) and cell type markers. The 11 genes comprising the refined signature (highlighted in bold) are shown on the right. (c) and (d) Density plots showing percentage expression of the murine disaggregation signature (c) and the refined disaggregation signature (d), in human lung tissue disaggregated for 15 and 60 minutes. Further data associated with this figure can be found in Fig. S6.