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. 2019 Jul 3;9:9596. doi: 10.1038/s41598-019-46116-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MMP-9 mRNA expression, MMP-9 and IL-1β immunoreactivity are down-regulated in NLRP3 KO mice cornea after alkali injury. MMP-9 mRNA expression is significantly down-regulated in NLRP3 KO mice cornea compared with those in WT mice after corneal alkali burn using quantitative RT-PCR (N = 8 each, WT mice; 1.2 ± 0.5 fold, NLRP3 KO mice; 0.4 ± 0.1 fold, P < 0.05). (a) In WT mice, extensive immunoreactivities of IL-1β (arrows) are observed in corneal stroma (b), but they are diminished in NLRP3 KO mice. (c) The cell counts of IL-1β positive cells (d) (N = 8 each, WT mice; 28.2 ± 9.6 cells/field, NLRP3 KO mice; 9.8 ± 2.6 cells/field, P < 0.01) has significant difference between WT mice and NLRP3 KO mice. Bar = 40 μm. Compared with WT mice (e), MMP-9 immunoreactivity (arrows) is diminished in NLRP3 KO mice. (f) The cell counts of MMP-9 positive cells (g) (N = 8 each, WT mice; 37.3 ± 9.7 cells/field, NLRP3 KO mice; 14.9 ± 6.3 cells/field, P < 0.01) are significantly decreased in NLRP3 KO mice. Bar = 40 μm.