Figure 6.

The Effect of Oral ASP on NPC Metastasis in Nude Mice

(A) The body weight comparison of the nude mice with and without ASP treatment. Control, ethyl alcohol. **p < 0.01. (B) Comparison of the metastatic node numbers in the lungs from mice in both groups. **p < 0.01. (C) Comparison of the liver weights from mice in both groups. ns, no significance. (D) Appearance of mouse lungs. Scale bar, 10 mm. (E) Histopathological examination of the metastatic tumors in the lungs by H&E staining. The arrow indicates the tumor location in the control. Scale bar, 50 μm. (F) Detection of CDH6 by IHC analysis for tracking the 5-8F tumor cells. Serial sections were used. PBS was used as a control corresponding to the CDH6 antibody in the IHC detection. The arrows indicate that tumor cells filled in the pulmonary alveoli. Scale bar, 100 μm.