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. 2019 Jun 12;17:223–234. doi: 10.1016/j.omtn.2019.06.001

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Local Administration of AgomiR-26a-5p Enhanced Fracture Healing in Mice

PBS, agomiR-26a-5p, and antagomiR-26a-5p were delivered locally to the fracture site on days 1, 3, and 7 after fracture. (A) mCT image comparison of fracture healing between control, agomiR-26a-5p, and antagomiR-26a-5p groups at day 21 after injury. (B–E) BV (B) and TV (C) of the callus, BV/TV (D), and BMD (E) on days 14 and 21 after the operation were determined by mCT. n = 6 mice/group. (F and G) Western blot analysis of Col1a1, ALP, OCN, and Runx2 levels in calluses of the control, agomiR-26a-5p, and antagomiR-26a-5p groups on days 14 (F) and 21 (G) after fracture. (H–K) qPCR analysis of Col1a1 (H), ALP (I), OCN (J), and Runx2 (K) expression in calluses of control, agomiR-26a-5p, and antagomiR-26a-5p animals on day 21 after fracture. Data are means ± SD of triplicate experiments. *p < 0.05, **p < 0.01, ***p < 0.001.