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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Mamm Genome. 2019 Mar 7;30(5-6):123–142. doi: 10.1007/s00335-019-09796-2

Figure 5.

Figure 5.

Lymphoid structure development. Lymph node anlage mesenchymal cells (MC) secrete CXCL13 that activates lymphoid tissue inducer (LTi) cells, which in turn induces the development of lymphoid tissue organizer (LTo) cells and creation of lymphoid structures. CXCL13 also recruits T helper follicular (Thf) CD4 cells and follicular DCs to the lymphoid structure that are important in the organization of lymphoid organs. Many of the signaling pathways important in this cascade are dependent on the IL2rγ-chain which is absent in IL2rγnull mice