Skip to main content
. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Drug Deliv Transl Res. 2019 Aug;9(4):802–815. doi: 10.1007/s13346-019-00630-5

Fig 1.

Fig 1

PNDJ structure and mechanism of dissolution. The polymer is composed of N-isopropylacrylamide (NIPAAm), Jeffamine M-1000 acrylamide (JAAm), and dimethylbutyrolactone acrylate (DBLA) monomers (pictured left to right in the structure). The JAAm side-chain is made up of ethylene oxide (EO) and propylene oxide (PO) repeat units in an approximate 19:3 ratio. PNDJ forms a hydrogel in vivo when the LCST is below body temperature. Hydrolytic ring-opening of the lactone in the DBLA side-chain increases the polymer LCST and leads to dissolution when the LCST exceeds body temperature