Fig 4.
Antimicrobial concentrations in PNDJ hydrogels recovered from 4 dosing sites after dosing with hydrogels containing 3% tobramycin and 2% vancomycin. (a) Total antimicrobials (tobramycin + vancomycin) measured at 6, 24, and 72 hr after dosing. Comparison of individual antimicrobial concentrations across dosing sites at (b) 24 hr and (c) 72 hr showed significant differences in tobramycin or vancomycin levels (adjusted p < 0.05) in sites compared to the femoral canal (*). Data are averaged across 2 hydrogel compositions (PNDJ1.09, PNDJ1.36) applied in 4 sites in 4 rabbits; error bars indicate standard deviation