Table 1:
Comparison of patients without and with a nosocomial infection
| No Nosocomial Infection (n = 2428) |
With Nosocomial Infection (n = 436) |
p-value |
|
|---|---|---|---|
| Admission Data | |||
| Age (years) | 57.22 (10.85) | 57.23 (10.39) | 0.70 |
| Gender (Male) | 63% (1527) | 57% (249) | 0.03 |
| Race (Caucasian) | 79% (1906) | 81% (351) | 0.30 |
| BMI | 29.93 (7.79) | 30.10 (11.45) | 0.18 |
| Etiology Alcoholic cirrhosis HCV HCV + alcoholic cirrhosis NASH Other |
30% (734) 21% (503) 14% (349) 21% (498) 14% (333) |
32% (139) 18% (80) 12% (52) 24% (106) 13% (57) |
0.23 |
| Diabetes | 34% (805) | 38% (164) | 0.09 |
| Admitted with infection | 23% (555) | 48% (208) | <0.0001 |
| Ascites | 69% (1674) | 75% (325) | 0.02 |
| Refractory ascites | 32% (770) | 40% (175) | 0.0006 |
| Hospitalized in last 6 months | 67% (1482) | 74% (281) | 0.005 |
| Medication used: PPI NSBB SBP prophylaxis Rifaximin Lactulose |
54% (1174) 41% (964) 17% (404) 35% (842) 54% (1293) |
59% (234) 38% (160) 23% (96) 41% (172) 62% (267) |
0.05 0.32 0.005 0.03 0.003 |
| On dialysis at admission | 3% (69) | 5% (21) | 0.05 |
| Admission SIRS (n, %) | 25% (592) | 37% (157) | <0.0001 |
| Temperature Component | 8% (204/2414) | 16% (70/432) | <0.0001 |
| Heart Rate Component | 39% (947/2418) | 47% (204/436) | 0.0028 |
| Respiratory Rate Component | 15% (367/2411) | 26% (114/433) | <0.0001 |
| WBC Component | 32% (781/2408) | 45% (193/429) | <0.0001 |
| Sepsis | 9% (213/2428) | 30% (131/236) | <0.0001 |
| Admission Lab values | |||
| Bilirubin | 5.74 (8.48) | 7.52 (9.14) | <0.0001 |
| Albumin | 2.86 (0.670 | 2.75 (0.69) | 0.003 |
| WBC | 7.49 (4.970 | 9.00 (7.24) | <0.0001 |
| INR | 1.67 (0.640 | 1.78 (0.60) | 0.0001 |
| Serum Sodium | 134.33 (7.05) | 133.35 (6.55) | <0.0001 |
| Serum creatinine | 1.49 (1.30) | 1.86 (1.56) | <0.0001 |
| Child-Pugh score | 9.46 (2.14) | 10.32 (2.11) | <0.0001 |
| MELD score | 19.05 (7.52) | 22.17 (8.06) | <0.0001 |
| Hospital Course | |||
| Episodes of AKI | 37% (777) | 69% (277) | <0.0001 |
| Length of hospital stay | 9.64 (10.51) | 28.04 (61.29) | <0.0001 |
| ICU admission | 18% (439) | 52% (227) | <0.0001 |
| Renal Failure | 5% (129) | 21% (91) | <0.0001 |
| Brain Failure | 12% (297) | 28% (118) | <0.0001 |
| Circulatory Failure | 6% (140) | 25% (106) | <0.0001 |
| Respiratory Failure | 9% (218) | 34% (147) | <0.0001 |
| Number of Organ Failures 0 1 2 3 4 |
76% (1850) 17% (416) 5% (113) 2% (38) 0.4% (7) |
46% (200) 22% (96) 16% (69) 13% (56) 3% (15) |
<0.0001 |
| NACSELD-ACLF | 7% (158) | 32% (140) | <0.0001 |
| Liver transplant | 3% (74) | 9% (38) | <0.0001 |
| 30-day survival | 92% (2244) | 72% (313) | <0.0001 |
ACLF defined as NACSELD-ACLF (2 or more of the following, brain failure: grade 3 / 4 hepatic encephalopathy, respiratory failure: mechanical ventilation or BiPAP, renal failure: renal replacement therapy and circulatory failure: shock) AKI: acute kidney injury, NSBB: non-selective beta-blockers