Skip to main content
. Author manuscript; available in PMC: 2020 Jul 2.
Published in final edited form as: Structure. 2019 May 23;27(7):1114–1123.e3. doi: 10.1016/j.str.2019.04.007

Figure 1. LPS trafficking and assembly in gram-negative bacteria.

Figure 1.

The lipid A core-subunit of LPS is flipped across the inner membrane (IM) by MsbA after its synthesis on the cytoplasmic side. Following the attachment of O-antigen on the periplasmic surface (not shown), LPS is delivered to the outer membrane (OM) through a complex of LPS transport proteins (Lpt A-G). The chemical structure of the hexa-acylated lipid A from E. coli or S. typhimurium with core sugar units attached to the 6′-hydroxy group of the lipid A glucosamine unit is shown on the right.