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. Author manuscript; available in PMC: 2020 Jul 2.
Published in final edited form as: Structure. 2019 May 23;27(7):1114–1123.e3. doi: 10.1016/j.str.2019.04.007

Figure 5. Conformational changes that accompany antagonist binding.

Figure 5.

(A) Side-by-side comparison of the MsbA structure in the presence of lipid A (left) with the LPS and G907-bound MsbA structure (6BPL, right). The inward motion of TM4 and TM5 towards TM6 encloses the binding site for G907 (green sphere) with a salt bridge formed between Arg190 and the carboxylate of G907. LPS is omitted for clarity but shown in (B) (yellow stick). (B) View of the conformational change from the cytosolic side of the two structures. (C) Alignment of TM4 and TM5 to further illustrate the G907-induced local conformational perturbation in TM4, including the unwinding of a helix turn (190–193). TM4 and TM5 in 6BPL are depicted in dark grey.