Table 2.
EBV haplotypes composed of SNPs 162215C>A, 162476T>C and 163364C>T and the risk for NPC
| EBV subtype (162215–162476–163364) | 639 cases |
652 controls |
Odds ratio* | 95% CI | P value | ||
|---|---|---|---|---|---|---|---|
| no. | % | no. | % | ||||
| L-L-L (A-T-C) | 25 | 3.91% | 171 | 26.23% | - | - | |
| H-H-H (C-C-T) | 539 | 84.35% | 293 | 44.94% | 11.71 | 7.44–19.26 | 2.39×10−24 |
| H-H-L (C-C-C) | 57 | 8.92% | 118 | 18.10% | 3.50 | 2.02–6.24 | 1.22×10−05 |
| H-L-L (C-T-C) | 13 | 2.03% | 65 | 9.97% | 1.12 | 0.47–2.50 | 7.83×10−01 |
| other subtypes | 5 | 0.78% | 5 | 0.77% | 4.26 | 0.80–19.63 | 6.71×10−02 |
*
Odds ratios of individual EBV subtypes and 95% confidence intervals (CI) were estimated with a logistic model by categorizing each subtype as a single variable and adjusting for age, sex, the status of single- or multiple-infection and human GWAS SNPs (rs2860580 and rs2894207) in the combined discovery and validation data sets. Subjects with EBV subtype A-T-C, a common low-risk subtype, were used as the reference category. H represents the high-risk genotype; L represents the low-risk genotype.