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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Cancer Res. 2019 Apr 25;17(7):1417–1428. doi: 10.1158/1541-7786.MCR-19-0147

Figure 3. H3K27me3 Staining in MPNST.

Figure 3.

MPNSTs frequently exhibit global loss of H3K27me3. (a,b) Immunohistochemical staining for H3K27me3 in MPNST tissue sections. Cells showing positive staining have been identified as inflammatory cells and endothelium (164). (c) H3K27me3 staining of granular neurons in human cerebellum, which exhibit high levels of H3K27me3, and serve as a positive control (117). Recent studies have highlighted the loss of this chromatin mark as an effective means of differentiating high grade MPNST from low grade MPNST and premalignant lesions. Images were provided by Drs. Sriram Venneti and Drew Pratt.