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. Author manuscript; available in PMC: 2019 Jul 5.
Published in final edited form as: J Med Chem. 2018 Feb 9;61(4):1450–1473. doi: 10.1021/acs.jmedchem.7b00738

Table 6.

In Vivo Efficacy Scout Screening

compd % inhibition day 3 PIa % inhibition day 6 PIa compd % inhibition day 3 PIa % inhibition day 6 PIa
8a  38.5 27.5 8u 100 98.3
8b  46.2 43.1 8v 100     100
8c  80.0 31.6 8w 100 82.4
8d  70.0 33.0 8x   80.0 19.3
8h 100       <1 8y 100 24.6
8k 100 12.3 8z 100 70.6
81  69.2 41.2 8aa 100 56.9
8m  40.0       <1 8ab 100     100
8n 100 39.2 8ad   46.2     <1
8o 100 98.0 8ag   84.6 31.4
8p 100     100 8ak 100 94.2
8q   46.2 15.7 8al 100 71.9
8r 100 24.6 8an 100     100
8s  80.0 14.0 8ao 100 86.4
8t 100       <1 atovaquone   96.3 99.8
amodiaquine  95.5 99.9
a

Percent inhibition compared to untreated animals.