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. 2019 Jul 4;19:150. doi: 10.1186/s12866-019-1522-7

Table 2.

BLI concentration required to restore imipenem susceptibility in efflux proficient and deficient P. aeruginosa

Compound Structure BLI concentration to restore IMI (μg/mL) Fold differentialb
MB6477 efflux-wta MB6476 efflux-dela
DABCO #1 graphic file with name 12866_2019_1522_Figa_HTML.gif > 100 12.5 > 8-fold
DABCO #2 graphic file with name 12866_2019_1522_Figb_HTML.gif 50 3.125 16-fold
DABCO #3 graphic file with name 12866_2019_1522_Figc_HTML.gif 12.5 6.25 2-fold
Relebactam graphic file with name 12866_2019_1522_Figd_HTML.gif 6.25 3.125 2-fold

BLI β-lactamase inhibitor, DABCO diazabicyclooctane, IMI imipenem

aMB6477 nfxC, wild-type for other efflux pumps, spontaneous OprD deletion; MB6476 nfxC, Δ [MexAB-OprM] Δ [MexCD-OprJ] Δ [MexXY] Δ [MexJKL] Δ [MexHI-OpmD] Δ [OpmH])

bDifferential between the concentrations required to restore susceptibility to imipenem at 4 μg/mL, expressed as the BLI concentration against MB6477 divided by the BLI concentration against MB6476