Table 3.
Distribution of imipenem MIC for P. aeruginosa isolates from the SMART global surveillance programa
| MIC μg/mL, n (cumulative %) | MIC90 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | ≥32 | |||
|
SMART 2009 (n = 993 isolates) |
IMI | 0 | 4 (0.4) | 12 (1.6) | 159 (17.6) | 308 (48.6) | 196 (68.4) | 38 (72.2) | 26 (74.8) | 100 (84.9) | 96 (94.6) | ≥32 |
| IMI/RELb | 0 | 14 (1.4) | 380 (39.7) | 306 (70.5) | 78 (78.3) | 92 (87.6) | 46 (92.2) | 18 (94.1) | 10 (95.1) | 10 (96.1) | 4 | |
|
SMART 2011 (n = 1702 isolates) |
IMI | 3 (0.2) | 4 (0.4) | 15 (1.3) | 92 (6.7) | 596 (41.7) | 437 (67.4) | 109 (73.8) | 73 (78.1) | 162 (87.6) | 123 (94.8) | ≥32 |
| IMI/RELb | 5 (0.3) | 9 (0.8) | 216 (13.5) | 883 (65.4) | 207 (77.6) | 143 (86.0) | 108 (92.3) | 37 (94.5) | 13 (95.2) | 13 (96.0) | 4 | |
|
SMART 2015 (n = 5953 isolates) |
IMI | NDc | NDc | NDc | 1035 (17.4)d | 2617 (61.3) | 540 (70.4) | 246 (74.6) | 579 (84.3) | 565 (93.8) | 371 (100.0) | 16 |
| IMI/RELb | 58 (1.0) | 214 (4.6) | 2120 (41.7) | 1934 (74.2) | 587 (84.0) | 453 (91.7) | 152 (94.2) | 111 (96.1) | 53 (97.0) | 181 (100.0) | 2 | |
|
SMART 2016 (n = 6165 isolates) |
IMI | NDc | NDc | NDc | 925 (15.0)d | 2593 (57.1) | 634 (67.3) | 278 (71.9) | 567 (81.1) | 671 (91.9) | 497 (100.0) | 16 |
| IMI/RELb | 49 (0.8) | 169 (3.5) | 1875 (33.9) | 2299 (71.2) | 564 (80.4) | 586 (89.9) | 154 (92.4) | 92 (93.9) | 68 (95.0) | 309 (100.0) | 4 | |
IMI imipenem, IMI/REL imipenem/relebactam, MIC minimum inhibitory concentration, ND not determined
aIncludes SMART surveillance data through October 2018
bImipenem combined with 4 μg/mL of relebactam
cThis MIC value was not tested
dThis value is for ≥0.5 μg/mL, since MIC values < 0.5 μg/mL were not tested