| Trial name or title | Thyroid dysfunction in the elderly: Quantifying the association between sub‐clinical disease and (i) atrial fibrillation (and thus stroke) (ii) depression and (iii) cognitive dysfunction. A community based survey and clinical trial of thyroxine therapy |
| Methods | |
| Participants | Phase 1: Aged 65+ Phase 2a: Patients identified in Phase 1 to be suffering from sub‐clinical hyperthyroidism Phase 2b: Patients identified in Phase 1 to be suffering from sub‐clinical hypothyroidism |
| Interventions | Intervention: Thyroxine replacement therapy. Dose to be
increased by 25 mcg steps during 6 monthly period of monthly monitoring of
thyroid function Control: As for intervention group but placebo |
| Outcomes | Not available |
| Starting date | 12 September 2002 |
| Contact information | Professor James V Parle ISRCTN23090699 |
| Notes |
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