. 2019 Jul 4;19:580. doi: 10.1186/s12879-019-4212-z

Table 1.

Candidate genes tested and their relevance in DENV control

Accession number	Gene name	Transcriptomic study	Function	Tissue	Direction	Differentially expressed	Interfamily variation
AAEL001022	smp-30/regucalcin	[12, 21]	Ca²⁺ binding domain	Whole	Down	Yes	-
AAEL001156	CG5280	[12, 13]	-	Whole	Up	No	Yes
AAEL001392	defA-assoc	[11–13, 20]	Immunity	Whole, Carcass	Down/Up	Yes	-
AAEL002413	sphingomyelin	[12]	Cellular membrane	Whole	Down	Yes	-
AAEL002585	CLIPA11	[12, 42]	Serine protease	Whole, MG	Down	No	Yes
AAEL003619	-	[12, 21]	Na/Cl transporter	Whole	Down	Yes	-
AAEL003787	Nopo	[12]	Zinc finger	Whole	Up	Yes	-
AAEL004361	alpha-glucosidase	[12]	Glycolysis	Whole	Down	Yes	-
AAEL004861	degringolade	[12, 13]	Peroxisomal integral protein	Whole, Carcass	Up	No	Yes
AAEL005064	CLIPB5	[12, 21]	Serine protease	Whole	Down	No	Yes
AAEL005527	Nbr/mut-7	[12, 13, 21]	miRNA maturation	Whole, SG	Down	No	Yes
AAEL006995	CG9657	[12, 21]	-	Whole	Down	No	No
AAEL007495	phosphoglycerate mutase	[12, 13, 21]	Glycolysis	Whole, Carcass, MG	Down	No	No
AAEL007845	Rab5	-	Receptor	-	-	Yes	-
AAEL008013	Obp83b	[12, 21]	Odorant	Whole	Down	No	Yes
AAEL008108	GB76c	[12, 13, 21]	Transmembrane signalling	Whole, Carcass, SG	Down	Yes	-
AAEL009317	Rab11	[12]	GTPase, cellular trafficking	Whole	Up	No	No
AAEL009602	Gdap1	[11, 12, 21]	Mitochondrial membrane	Whole, Midgut	Down	No	No
AAEL009770	SUMOE2	[12]	Sumoylation	Whole	Up	Yes	-
AAEL011375	trypsin	[12, 13, 21]	Serine protease	Whole, Carcass	Down	Yes	-
AAEL011566	-	[11, 12, 21]	Adhesion	Whole, Carcass, MG	Down	Yes	-
AAEL011817	rent1	[12]	mRNA decay	Whole	Down	No	Yes
AAEL012089	xport-A	[11, 12, 21]	Phototransduction	Whole, Carcass	Down	No	No
AAEL013712	Trypsin 5G1 precursor	[11, 12, 21]	Serine protease	Whole, Carcass	Up	No	No
AAEL014108	aquaporin	[12, 13, 21]	H₂O Transporter	Whole, Carcass	Down	Yes	-

Accession numbers, gene names, function and patterns of expression across families with high and low DENV loads for the tested genes. All had been previously reported in transcriptomic studies associated with differences in expression in at least two conditions (tissues/timepoints). Tissues of previous reported expression differences are shown. In “Tissue”, MG and SG correspond to midgut and salivary glands, respectively. Whether the genes were up or downregulated in those studies can be seen in “Direction”, and our reported expression patterns are shown in the column “Differentially expressed” as well as “Interfamily Variation”