. 2019 May 27;10(26):6531–6538. doi: 10.1039/c9sc00978g

Table 2. Asymmetric synthesis of γ-chloro and δ-chloro tertiary alcohols by addition of Grignard reagents to γ-chloro and δ-chlorobutyrophenones ^a ^b ^c .

^aProcedure as for Table 1, entry 8.

^bIsolated yields.

^cEnantiomeric excess determined by HPLC analysis on chiral stationary phase.

^dResults in brackets refers to the opposite enantiomer obtained by using (S,S)-L1.

^eAbsolute configuration from derived compound 9.

^fAbsolute configuration determined by conversion to urethane 8 – see text and Fig. 2, configurations of other compounds shown assumed by analogy, see text.

Table 2. Asymmetric synthesis of γ-chloro and δ-chloro tertiary alcohols by addition of Grignard reagents to γ-chloro and δ-chlorobutyrophenones a b c .

Table 2. Asymmetric synthesis of γ-chloro and δ-chloro tertiary alcohols by addition of Grignard reagents to γ-chloro and δ-chlorobutyrophenones ^a ^b ^c .