Table 2. Patient features and correlation with establishment of spheres.
There were no significant associations with neurosphere establishment (Chi-square). L1, L2, M or MS stage disease at diagnosis used the International Neuroblastoma Risk Group (INRG) Classification System.
| Number (%) | Successful Establishment
of spheres (%) |
||
|---|---|---|---|
| Gender | |||
| Male | 37 (55) | 22 (59) | |
| Female | 30 (45) | 15 (50) | |
| Age | |||
| <=18months | 36 (54) | 23 (64) | |
| >18months | 31 (46) | 14 (45) | |
| INRG Stage at Diagnosis | |||
| L1 | 3 (4) | 2 (67) | |
| L2 | 21 (31) | 14 (67) | |
| M | 39 (58) | 18 (46) | |
| MS | 4 (6) | 3 (75) | |
| NMYC Amplification | |||
| Yes | 17 (25) | 7 (41) | |
| No | 50 (75) | 30 (60) | |
| Segmental Chromosomal Abnormalities | |||
| Yes | 21 (31) | 14 (67) | |
| No | 46 (69) | 23 (50) | |
| Tumor Biology | |||
| Undifferentiated | 47 (70) | 28 (60) | |
| Differentiating | 20 (30) | 9 (45) | |