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Efficacy of MFS alone or in combination with LPV in L. infantum in vivo infection. Evaluation of hepatic (A) and splenic parasite burden (B) 30 days post-infection. CI, infected control. Animals were treated in day 7 post-infection by oral gavage twice daily for 5 days with a 12 h interval between doses. Data are presented as the mean ± SD. *P < 0.05; **P < 0.01; ****P < 0.0001 versus CI. #P < 0.05 vs. MFS 3.85; ##P < 0.01 vs. MFS 3.85.
