Fig. 2.

Clinical photographs of the patient's eye before (A) and after (B,C,D) autologous cultivated oral mucosal epithelial transplantation (COMET). COMET was performed combined with keratectomy, amniotic membrane transplantation, and PEA + IOL for end-stage ocular pemphigoid with keratinization and symblepharon (A). Symblepharon was successfully released, and non-keratinized epithelium derived from the cultivated oral mucosal epithelial cell sheet covered the entire corneal surface at 3-years post COMET (B), and BCVA improved from hand motion to count fingers post COMET. Fluorescein staining of the same eye post-COMET showed no epithelial damage (C). COMET enabled the use of a tear-exchangeable, limbal, rigid CL, and BCVA improved to 0.05 via the use of this CL (D).