Table 1.
Summary of Published Studies Using Limbal Epithelial Stem Cells.
| ARTICLE (ref) | NUMBER OF EYES/Px | AUTO/ALLO-GRAFT | TISSUE TYPE | FEEDER CELL LAYER | SUBSTRATE | PATHOLOGY | MEAN FOLLOW UP (MONTHS) | VA IMPROVEMENT* | SUCCESS RATE* |
|---|---|---|---|---|---|---|---|---|---|
| Tsubota et al. 1999 [70] | 43/39 | Allo | LESC | N | AM | SJS/OCP 25 Therm/Chem 14 |
28.2 | 60% | – |
| Schwab et al. 2000 [43] | 14/14 | Auto 10 Allo 4 |
LESC LRD |
Y | D-AM | NS | 13 | – | 71.4% |
| Tsai et al. 2000 [15] | 6/6 | Auto | LESC | N | AM | Chem 3 Other 3 |
15 | 83% | – |
| Koizumi et al. 2001 [27] | 13/11 | Allo | CAD | Y | D-AM | SJS 7 OCP 2 Chem 3 Other1 |
11.2 | – | – |
| Grueterich et al. 2002 [71] | 1/1 | Auto | LESC | N | AM | Chem 1 | 21 | – | – |
| Shimazaki et al. 2002 [44] | 13/13 | Allo | CAD 7 LRD 6 |
Y | AM | SJS 8 OCP 3 Chem 2 |
NS | – | 46.2% |
| Sangwan et al. 2003 [72] | 2/1 | Auto | LESC | Y | D-AM | Chem 1 | 12 | – | – |
| Nakamura et al. 2004 [73] | 1/1 | Auto | LESC | Y | D-AM | Chem 1 | 19 | – | 100% |
| Daya et al. 2005 [23] | 10/10 | Allo | CAD 9 LRD 1 |
Y | AM | SJS 3 Therm/Chem 3 Other 4 |
28 | 40% | 70% |
| Nakamura et al. 2006 [33] | 9/9 | Auto 2 Allo 7 |
LESC CAD |
Y | D-AM | SJS 2 OCP 1 Chem 1 Aniridia 1 Idiopathic 2 Other 2 |
14.6 | 100% | 100% |
| Sangwan et al. 2006 [74] | 88/86 | Auto | LESC | N | D-AM | Therm/Chem 78 Other 10 |
18.3 | – | 73.1% |
| Ang et al. 2007 [75] | 2/1 | Allo | CAD | Y | D-AM | SJS 1 | NS | – | – |
| Fatima et al. 2007 [76] | 1/1 | Auto | LESC | Y | AM | Chem 1 | 37 | – | 60% |
| Shimazaki et al. 2007 [77] | 27/27 | Auto 7 Allo 20 |
LESC CAD 12 LRD 8 |
N Y |
D-AM AM |
SJS 13 OCP 4 Therm/Chem 9 Other 1 |
29.2 | 48.1% | 59.3% |
| Kawashima et al. 2007 [78] | 6/6 | Auto 2 Allo 4 |
LESC LRD 1 CAD 3 |
Y Y |
D-AM | Chem 3 SJS 2 Pseudo-OCP 1 |
6.8 | – | – |
| Shortt et al. 2008 [79] | 10/10 | Auto 3 Allo 7 |
LESC CAD |
N | AM | Chem 4 Aniridia 3 ED 1 Reiger’s Anomaly 1 Other 1 |
13 | – | 60% |
| Kolli et al. 2009 [80] | 8/8 | Auto | LESC | Y | AM | NS | 19 | 62.5% | 100% |
| Meller et al. 2009 [81] | 1/1 | Allo | LRD | NS | AM | Other 1 | 31 | – | – |
| Satake et al. 2009 [82] | 1/1 | Auto | LESC | Y | D-AM | Other 1 | 43 | – | – |
| Baradaran-Rafii et al. 2010 [83] | 8/8 | Auto | LESC | N | D-AM | Therm/Chem 8 | 34 | – | – |
| Thanos et al. 2010 [84] | 1/1 | Auto | LESC | N | AM | Other 1 | 28 | – | – |
| Sangwan et al. 2011 [35] | 200/200 | Auto | LESC | N | D-AM | Therm/Chem 200 | 36 | 60.5% | 71% |
| Sharma et al. 2011 [85] | 50/50 | Auto 34 Allo 16 |
LESC 34 CAD 9 LRD 7 |
N | D-AM | Therm/Chem 18 Other 2 NS 30 |
11 | 68% | 74% |
| Basu et al. 2012 [86] | 50/50 | Auto | LESC | N | D-AM | Therm/Chem 50 | 27.6 | 76% | 66% |
| Prabhasawat et al. 2012 [87] | 19/18 | Auto 12 Allo 7 |
LESC CAD |
N | D-AM | Therm/Chem 13 SJS 1 Other 5 |
26.1 | 68.4% | 73.7% |
| Pathak et al. 2012 [11] | 9/9 | Auto | LESC | N | AM | Therm/Chem 8 Other 1 |
11-28 | – | 55.6% |
| Sejpal et al. 2013 [88] | 107/107 | Auto | LESC | N | D-AM | Therm/Chem 107 | 41.2 | 54.2% | 46.7% |
| Sharma et al. 2013 [89] | 4/4 | Auto | LESC | NS | D-AM | Therm/Chem 4 | 19.5 | 100% | – |
| Subramaniam et al. 2013 [90] | 40/39 | Auto | LESC | N | D-AM | Therm/Chem 36 Other 4 |
33 | 38% | – |
| Qi et al. 2013 [91] | 42/41 | Allo | CAD | Y | D-AM | Therm/Chem 41 | 12 | – | – |
| Amescua et al. 2014 [45] | 4/4 | Auto | LESC | N | AM | Chem 2 Trauma 1 Melanoma 1 |
7.5 | 100% | 100% |
| Qi et al. 2014 [92] | 16/15 | Allo | CAD | Y | D-AM | Therm/Chem15 | 12 | – | 80% |
| Vazirani et al. 2014 [93] | 70/70 | Auto | LESC | N | D-AM | Therm/Chem 64 OCP 1 Idiopathic 1 Other 4 |
17.5 | – | – |
| Zakaria et al. 2014 [94] | 18/12 | Auto 15 Allo 3 |
LESC CAD 1 LRD 2 |
N | D-AM | Chem 7 Aniridia 2 Other 9 |
24 | – | 67% |
| Ramírez et al. 2015 [95] | 20/19 | Auto 11 Allo 9 |
LESC CAD |
N | D-AM | Chem 7 SJS 3 Aniridia 2 Other 8 |
36 | – | 80% |
AM=Human Amniotic Membrane. Allo = Allograft. Auto = Autograft. CAD = Cadaver. Chem = Chemical. D-AM = Denuded Human Amniotic Membrane. ED = Ectodermal Dysplasia. LESC = Limbal Epithelial Stem Cells. LRD = Living Relative Donor NS = Not Stipulated. OCP = ocular cicatricial pemphigoid. Px = Patient. SJS = Steven Johnson syndrome. Therm = Thermal. VA = Visual Acuity.
*
Areas void of information are the result of values not explicitly being provided in the relevant journal articles.