Table 2.
Summary of Published Studies Using Oral Mucosal Epithelial Cells.
| ARTICLE (ref) | NUMBER OF EYES/Px | AUTO/ALLO- GRAFT | TISSUE TYPE | FEEDER CELL LAYER | SUBSTRATE | PATHOLOGY | MEAN FOLLOW UP (MONTHS) | VA IMPROVEMENT* | SUCCESS RATE* |
|---|---|---|---|---|---|---|---|---|---|
| Nakamura et al. 2004 [46] | 6/4 | Auto | Oral | Y | D-AM | SJS 3 Chem 3 |
13.8 | 100% | – |
| Nishida et al. 2004 [29] | 4/4 | Auto | Oral | Y | TRS | SJS 1 OCP 3 |
14 | 100% | – |
| Ang et al. 2006 [49] | 10/10 | Auto | Oral | Y | D-AM | Therm/Chem 2 SJS 7 OCP 1 |
12.6 | 90% | – |
| Inatomi et al. 2006 [96] | 2/2 | Auto | Oral | Y | D-AM | Chem 1 SJS 1 |
22.5 | – | – |
| Inatomi et al. 2006 [48] | 15/12 | Auto | Oral | Y | D-AM | Therm/Chem 6 SJS 7 Pseudo-OCP1 Other 1 |
20 | 67% | 67% |
| Nakamura et al. 2007 [97] | 6/5 | Auto | Oral | NS | AM | SJS 3 Chem 3 |
NS | – | 66.7% |
| Satake et al. 2008 [98] | 4/4 | Auto | Oral | Y | D-AM | SJS 2 Pseudo-OCP 2 |
6-24 | – | – |
| Chen et al. 2009 [99] | 4/4 | Auto | Oral | Y | D-AM | Therm/Chem 4 | 22 | – | – |
| Ma et al.2009 [100] | 6/5 | Auto | Oral | Y | D-AM | Therm/Chem 5 | 29.6 | – | – |
| Nakamura et al. 2010 [47] | 19/17 | Auto | Oral | Y | D-AM | Therm/Chem 1 SJS 11 OCP 4 Other 3 |
55 | 95% | – |
| Priya et al. 2011 [101] | 10/10 | Auto | Oral | Y | D-AM | SJS 1 Chem 9 |
18.6 | – | – |
| Takeda et al. 2011 [102] | 3/3 | Auto | Oral | Y | D-AM | Therm/Chem 3 | 30 | – | – |
| Burillon et al. 2012 [103] | 26/25 | Auto | Oral | Y | TRS | Therm/Chem 9 Aniridia 3 Other 14 |
12 | – | 64% |
| Chen et al. 2012 [104] | 6/6 | Auto | Oral | Y | D-AM | Therm/Chem 6 | 36.7 | – | – |
| Sotozono et al. 2013 [52] | 46/40 | Auto | Oral | Y | AM | Therm/Chem 7 SJS 21 OCP 10 Other 8 |
28.7 | 48% | – |
| Kolli et al. 2014 [34] | 2/2 | Auto | Oral | N | AM | Chem 2 | 24 | – | – |
| Sotozono et al. 2014 [51] | 10/9 | Auto | Oral | Y/N | D-AM | Therm/Chem 5 SJS 3 OCP 2 |
23.3 | – | – |
| Prabhasawat et al. 2016 [50] | 20/18 | Auto | Oral | N | D-AM | Chem/Therm 7 SJS 10 Others 3 |
31.9 | 70% | 75% |
Allo = Allograft. AM=Human Amniotic Membrane. Auto = Autograft. CAD = Cadaver. D-AM = Denuded Human Amniotic Membrane. Therm = Thermal. Chem = Chemical. LRD = Living Relative Donor. NS = Not Stipulated. OCP = ocular cicatricial pemphigoid. Px = Patient. SJS = Steven Johnson syndrome. TRS = Temperature Responsive Surface. VA = Visual Acuity.
*
Areas void of information are the result of values not explicitly being provided in the relevant journal articles.