Table 2.
Clinical Features and viral load in the corneal scraping of patients diagnosed as HSV keratitis by real time qPCR
| S. No. (Patient. #) | Pre disposing factor | Initial VA | Clinical Diagnosis | Treatment | Final VA | PCR | q HSV-1 copies/mL | Microbiology culture |
|---|---|---|---|---|---|---|---|---|
| 1 (1) | Contact lens | HM+ | HSV stro Stromal Keratitis | ACV + Mx + At | 20/200p | + | 2.55x10^6 | NG |
| 2 (5) | Injury (stick) | HM+ | NNeurotrophic keratitis | Cz + Cip + At | HM+ | 76.7 | S. epidermidis | |
| 3 (8) | Injury | 20/60 | Epithelial Keratitis | ACV + Pf | 20/40 | - | 1.38x10^7 | - |
| 4 (9) | Injury | CFCF | Infectious KERATITIS | Mx + At + Pf | 20/125p | - | 179 | NG |
| 5 (10) | injury | 20/40 | Infectious KERATITIS | Nat + At | LFU | - | 96 | S.epidermidis Microbacterium sp. |
| 6 (12) | - | 20/80 | Epithelial Keratitis | ACV | 20/20 | + | 2.26×10^3 | ND |
| 7 (15) | h/o HERPES ZOSTER infection | HM+ | Neurotrophic keratitis | Cz + ACV + Cip | HM+ | - | 1.20×10^2 | S.aureus |
| 8 (16) | - | HM+ | Epithelial Keratitis | ACV + At | HM+ | - | 6.52×10^5 | NG |
| 9(17) | - | FFL | Epithelial Keratitis | ACV | FFL | + | 1.25×10^7 | NG |
| 10 (18) | Injury (stick) | 20/800 | Infectious KERATITIS | Nat + KTZ + Ch | 20/50 | + | 2.40×10^2 | UID |
| 11 (19) | injury (dust) | 20/60p | Infectious KERATITIS | Cz + At + Cip | 20/50p | + | 189 | P.acnes |
| 12 (20) | - | 20/600 | Epithelial Keratitis | Cz + ACV + Cip + Mx | PK | + | 3.49×10^5 | ND |
| 13 (21) | Injury | HM+ | Infectious KERATITIS | Cz + Mx | PK | + | 7.57×10^3 | NG |
| 14 (22) | - | 20/400 | stromal Keratitis | ACV | CFCF | 8.00×10^4 | NG | |
| 15 (23) | HSV -reactivation | CFCF | Epithelial Keratitis | ACV + Cip + Cz | 20/25 (pinhole) | - | 63.1 | Sphingomonas paucimobilis S.epidermidis |
| 16 (24) | h/o jaundice | CF 2m | Infectious KERATITIS | Cz + Cip | 20/60p (unaided) | + | 2.08×10^2 | S.pneumoniae |
| 17 (25) | HSV -reactivation | 20/60p | stromal keratitis | ACV | 20/60p | + | 2.56×10^2 | NG |
| 18 (26) | - | HM+ | Microbial Keratitis | Cz + Cip + PHMB + Chlorhexidine | HM+ | - | 1.82×10^2 | Acanthamoeba species |
| 19 (27) | - | CF 1m | stromal keratitis | Cz + ACV + Cip | PK | - | 3.52×10^3 | Sphingomonas paucimobilis |
| 20(28) | - | CFCF | stromal keratitis | Cz + ACV | 20/80p | - | 8.63×10^3 | NG |
| 21 (29) | - | HM+ | Fungal KERATITIS | Nat | 20/20 | - | 1.31×10^2 | Fusarium solani |
| 22 (30) | HSV -reactivation | 20/125p | stromal keratitis | ACV + Ch | 20/40 | + | 50.5 | ND |
| 23 (32) | - | HM+ | MICROBIAL KERATITIS | Cz + Cip | HM+ | - | 1.55×10^2 | NG |
| 24 (33) | injury(sugarcane) | CF1m | HSV -Stromal Keratitis | ACV + Ch | 20/40p | - | 5.93×10^3 | NG |
| 25 (34) | - | 20/500 | HSV stromal keratitis | Cz + ACV + Cip | 20/400 | + | 4.42×10^4 | Sphingomonas paucimobilis |
| 26 (35) | - | 20/100 | HSV stromal keratitis | ACV + Mx | 20/80 | + | 5.85×10^4 | Sphingomonas paucimobilis |
| 27 (36) | - | CFCF | HSV -Stromal Keratitis | Cz + ACV + Cip + Ch | 20/200 | + | 99.1 | Staphylococcus haemolyticus |
| 28 (37) | - | PL+PR+ | MICROBIAL KERATITIS | Ch | PL + PR Accurate | - | 2.03×10^2 | NG |
| 29 (38) | HSV -reactivation | PL+PR + | HSV stromal keratitis | ACV + Ch | HM+ | + | 6.15×10^3 | NG |
| 30 (39) | - | CFCF | HSV stromal keratitis | ACV + Ch | PK | + | 4.30×10^3 | NG |
| 31 (40) | - | CF 1m | HSV Stromal Keratitis | Mx + ACV + Pf | 20/320 | + | 1.86×10^5 | NG |
| 32 (41) | Injury (stick) | HM+ | HSV Stromal Keratitis | Mx + ACV + Pf | 20/600 | + | 1.55×10^7 | Methylobacterium sp. |
| 33 (42) | - | CFCF | HSV Stromal Keratitis | Cz + ACV + Cip | PL+PR Accurate | + | 4.29×10^3 | NG |
| 34 (44) | - | HM+ | MICROBIAL KERATITIS | At + Ch + Pf | HM+ | - | 39.7 | NG |
| 35 (45) | post-PK | HM+ | HSV Epithelial Keratitis | Cz + At + Cip | LFU | - | 9.00×10^4 | NG |
| 36 (46) | - | PL+PR- | HSV Stromal Keratitis w/o sec fungal | Cz + ACV + Cip + KTZ + Nat | PK | - | 7.69×10^3 | Alternaria species |
| 37 (47) | - | CF 1m | Fungal KERATITIS | Nat | CF 1m | + | 8.81×10^3 | (fungal filaments on smear) NG |
| 38 (49) | - | CFCF | HSV stromal and epithelial keratitis | ACV + Ch | 20/125 | - | 8.16×10^4 | NG |
| 39 (50) | HM | HSV Stromal Keratitis | Ch + ACV + KTZ + Nat | LFU | + | 6.19×10^2 | Curvulariasp. |
Legend: HM+: Hand Movements; FFL: Following and fixing light; CFCF: Counting fingers close to face; CF: Counting fingers; PL+PR-: Accurate Projection of Light, Inaccurate projection of rays; PL+PR+: Accurate Projection of Light, accurate projection of rays, NG: No growth; ACV: Acyclovir; Ch: Chloramphenicol, Mx: Moxifloxacin; Nat: natamycin; KTZ: Ketoconazole; Cip: Ciprofloxacin; At: Atropine; Pf: Predforte; PHMB: Polyhexa methylene biguanide