Fig. 4.

Starting with the same data sets, each modeling and simulation (M & S) team goes through a sequence of modeling and simulation phases to come up with their own flavor of models representing the knee specimens of the data sets. The overarching goal of this study is to understand if the decisions of the modeling teams influence simulation predictions, and their interpretation to reach scientific and clinically relevant conclusions. Dissemination of all modeling and simulation outcomes and documentation of the whole lifecycle of the models will provide the opportunity to understand the source of variations in modeling decisions and the motivations behind them.