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. 2019 Jun 19;10:627. doi: 10.3389/fneur.2019.00627

Table 1.

Descriptive checklist of the included studies.

Article Subjects Interventions Outcomes (only intergroup differences are presented)
OLDER ADULTS
Lam et al. (50) 73 older adults, 40 women, mean age: 82.3 ± 7.3 years.
WBV + exercise (WBV+E): n = 25, 12 men, 13 women, mean age 84 years
Exercise: n = 24, 10 men, 14 women, mean age 82.4 years.
Control: n = 24, 11 men, 13 women, mean age 80.3 years.
8weeks, 3 times per week.
WBV + E: Fitvibe medical WBV system (GymnaUniphy NV, Bilzen, Belgium), dynamic exercises, 4 × 1min/1–2min, 30 Hz (weeks 1–4) and 40 Hz (weeks 5–8), 0.9 mm, vertical displacements.
Exercise: identical exercise program without WBV.
Control: social and recreational activities that only involved the upper limbs.
WBV + E vs. Exercise: No significant effect for TUG (SMD = −0.18, 95% CI: −0.74, 0.38) and the 6MWT (SMD = 0.21, 95% CI: −0.35, 0.78).
Wei et al. (69) 80 community dwelling seniors with sarcopenia.
Low frequency group: n = 20, 7 men, 13 women, mean age 78 years
Medium frequency group: n = 20, 7 men, 13 women, mean age 75 years
High frequency group: n = 20, 5 men, 15 women, mean age 74 years
Control group: n = 20, 5 men, 15 women, mean age 76 years
3 days/week over a 12-week period,
WBV: 4 mm for all training groups, knee joint flexed at 60°, Fitvibe excel, GymnaUniphy NV, Bilzen, Belgium, vertical vibrations.
Low frequency group: 20Hz × 720s
Medium frequency group: 40Hz × 360s
High frequency group: 60Hz × 240s
Control group: no extra training
Low frequency group vs. control: no significant difference for the TUG test (SMD = −0.22, 95% CI: −0.84, 0.41)
Medium frequency group vs. control: no significant difference for the TUG test (SMD = −0.40, 95% CI: −1.03, 0.22)
High frequency group vs. control: no significant difference for the TUG test (SMD = −0.30, 95% CI: −0.92, 0.33)
Goudarzian et al. (45) 42 healthy old men.
WBV: n = 11, mean age 66, 58 years.
MT: n = 12, mean age 69, 20 years.
WBV+MT: n = 10, mean age 67, 80 years.
Control: n = 9, mean age 68, 90 years.
3 times a week, 8 weeks
WBV: Novotec, Pfor- zheim, Germany, static and dynamic exercises, 6 × 45–85s/45–85s, 30–35 Hz, 5–8 mm, n
MT: relaxation techniques.
WBV+MT: combination of vibration and MT that was the half-time of each protocol.
Control: Daily routine.
WBV vs. Control: no difference between group for the TUG test (SMD = −0.60, 95% CI: −1.50, 0.31).
Significant improvement of the 10MWT in favor of the WBV (SMD = −1.32, 95% CI: −2.32, −0.33).
Sitjà-Rabert et al. (64) 159 older people, 107 women, 52 men, with a mean age of 82 years.
WBV + exercise group: n = 81, n
Exercise group: n = 78, n
6 weeks, 3 sessions per week.
WBV + exercise group: Pro5 Airdaptive Model; PowerPlate, Amsterdam, The Netherlands, static/dynamic exercises, n, 30–35 Hz, 2–4 mm, n
Exercise group: same static/dynamic exercises without vibration platform.
WBV + exercise group vs. exercise group:
No difference between group for the TUG test (SMD = −0.02, 95% CI: −0.39, 0.34)
No difference between group for the Tinetti gait score (SMD = −0.08, 95% CI: −0.44, 0.27)
Santin-Medeiros et al. (62) 37 elderly women, mean age 82.4 years.
WBV group: n = 25.
Control group: n = 18.
8-month, 2 sessions per week
WBV: Fitvibe Excel Pro; GymnaUniphy NV Bilzen, Belgium,18 exercises, 6/session, 1–2 sets/exercise, 30–35/exercise, 6 min-6 min50 s/ session, 20 Hz, 2 mm.
Control: maintain their habitual lifestyle
WBV vs. control: Groups were statistically different at baseline for the TUG test.
WBV: No significant improvement of the TUG test post WBV (SMD = 0.15, 95% CI: −0.49, 0.78).
Buckinx et al. (36) 62 nursing home residents.
WBV group: n = 31, 11 men, 20 women, mean age 82.2 years.
Control group: n = 31, 3 men, 27 women, mean age 84.2 years.
6 months, 3 training sessions every week.
WBV group: Vibrosphère,
knees flexed, 5 × 15 s/30 s, 30 Hz, 2 mm, vertical vibrations.
Control group: normal daily life.
Lack of data post WBV.
WBV vs. control: authors reported no significant inter group difference for the TUG test, Tinetti gait score and for the parameters recorded by the Locometrix (p > 0.05).
Lee et al. (53) 55 Elderly Patients with Diabetic Neuropathy
WBV + BE group: n = 19, 9 men, 10 women, mean age 76.31 years.
Balance exercise group (BE): n = 18, men:7, women:11, mean age: 74.05 years.
Control group: n = 18, 8men, 10 women, mean age 75.77 years.
6 weeks, twice per week, same physical therapy.
WBV + BE group: Galileo 2000, Novotec Medical GmBH, Germany, 3/week, squatting position, 3 × 3min/1-min, 15-30 Hz, 1–3 mm, n
BE group: strength, balance, and functional mobility training.
Control group: n
WBV + BE group vs. BE group:
Significant improvement of the TUG test in favor of the WBV group (SMD = −0.72, 95% CI: −1.39, −0.06).
Beaudart et al. (31) 62 nursing home residents.
WBV group: n = 31, 11 men, 20 women, mean age 82.2 years.
Control group: n = 31, 4 men, 27 women, mean age 84.2 years.
3 months, 3 training sessions every week.
WBV: Vibrosphere, static position with a knee flexion, 5 × 15/30 s, 30 Hz, 2mm, vertical vibrations.
Control group: requested neither to change their lifestyle during the study nor to get involved in any new type of physical activity.
WBV vs. control:
No significant difference between groups for the TUG test (SMD = −0.10, 94% CI: −0.59, 0.40) and the Tinetti test (SMD = 0.30, 95% CI: −0.20, 0.80).
Lack of data post WBV for the Locometrix system.
The authors reported no significant inter group difference for the parameters recorded by the Locometrix (p > 0.05).
Gómez-Cabello et al. (44) 49 non-institutionalized elderly (20 men and 29 women; aged 75.0 ± 4.7 years).
WBV: n = 24, n
Control: n = 25, n
11 weeks, 3 times per week.
WBV: Pro5 Power plate, London, UK, squat position, 10 × 45/60s, 40Hz, 2mm.
Control: not participate in any training. Asked not to change their lifestyle.
WBV vs. control: No difference between group for the 6MWT (SMD = 0.54, 95% CI: −0.03, 1.11).
Bogaerts et al. (32) 111 elderly women over 70 years of age
WBV group: n = 54
Control group: n = 57
6 mouths, 3 sessions per week;
WBV group: Powerplate, 2–5 dynamic exercises. 4 × 15s/60s (start of the study), 12 × 60s//5s (6mouths). 30-40HZ, 1,6–2,2g, n
Control group: no training program.
WBV vs. control group: No significant difference for the TUG test (SMD = −0.18, 95% CI: −0.55, 0.20) and the 10MWT
(SMD = −0.26, 95% CI : −0.63, 0.12) at preferred speed.
No significant difference for the TUG test (SMD = −0.31, 95% CI: −0.68, 0.07) and the 10MWT
(SMD = −0.10, 95% CI: −0.47, 0.27) at maximum speed.
Mikhael et al. (56) 19 older adults mean age 64, 4 years (range 50–80).
WBV with flexed knees (FK): n = 6, 4 men, 2 women, mean age 63.3 years
WBV with locked knees (LK): n = 5, 3 men, 2 women, mean age 69 years
Sham: n = 8, 4 men, 4 women, mean age 62.3 years
20 min, 3 days per week, 3 months, static exercises, 39 × 1min/1min, 12 Hz, 1 mm
WBV with FK: vibration platform engineered by Australian Catholic University (2004), knee angle at 20
WBV with LK: lock knees
Sham: The amplitude was set to 0 mm, giving 0 g magnitude.
Lack of data post WBV.
The authors reported no between groups difference after WBV for the 6MWT (p = 0.61), habitual and maximal gait velocities (p = 0.80 and p = 0.58, respectively).
Machado et al. (55) 26 community-dwelling elderly women
WBV: n = 13, mean age 79.3 years
Control: n = 13, mean age 76.2 years
3–5 times a week, 10 weeks
WBV: Fitvibe, GymnaUniphy NV, Bilzen, Belgium, half squat, deep squat, wide stance squat, calves, 1–2 sets/exercise, 30–60 s/120–180 s, 2–4 mm, 20–40 Hz, increased progressively, n
Control: requested to do not change their lifestyle during the study
Lack of data post WBV. The authors reported a significant improvement of the TUG test post WBV(p < 0.05) but no significant difference between groups (p > 0.05).
Furness and Maschette. (40) 73 older adults, 38 females and 35 males, mean age 72 ± 8 years
1 WBV session per week: n
2 WBV sessions per week: n
3 WBV sessions per week: n
Control group: n
0, 1, 2, or 3 times a week, 6 weeks.
WBV interventions: n, static, knees flexes at 110°, 5 × 1min/1min, 15–25 Hz, 0,5mm, vertical vibrations.
Control group: The zero group did not participate in any WBV sessions.
1 WBV vs. control: No significant between group difference for the TUG test (SMD = 0.57, 95% CI : −0.10, 1.24)
2 WBV vs. control: No significant between group difference for the TUG test (SMD = 0.57, 95% CI: −0.10, 1.24)
3 WBV vs. control: No significant between group difference for the TUG test (SMD = −0.45, 95% CI: −1.11, 0.20)
Rees et al. (59) 43 older adults, untrained, 23 men and 20 women
WBV group: n = 15, mean age 74.5 years
Exercise group: n = 13, mean age 73.1 years
Control group: n = 15, mean age 73.1 year
3 sessions a week, 8weeks, low- intensity walking at least 3 times a week
WBV group: Novotec, Pforzheim, Germany, static and dynamic exercises, 6 × 45–80s/45–80s, 26 Hz, 5–8 mm, increased progressively, vertical displacements.
Exercise group: same exercises without WBV.
Control group: low intensity walking
WBV vs. exercise group:
No significant difference between groups for the TUG test (SMD = −0.35, 95% CI: −1.10, 0.40) and the 10MWT (SMD = −0.25 95% CI: −0.99, 0.50).
WBV vs. control: no significant difference between group for the TUG test (SMD = −0.22, 95% CI: −0.75, 0.31) and the 10MWT test (SMD = −0.29, 95% CI: −1.01, 0.43).
Bautmans et al. (30) 24 older adults, nursing home residents.
WBV: n = 13, 5 men, 8 women, mean age 76.6 years.
Sham: n = 11, 4 men, 7 women, mean age 78.6 years.
3 times weekly, 6 weeks
WBV: Power- Plate, Badhoevedorp, The Netherlands, 2–4 static lower limb exercises/sessions, 1–3 × 30–60s/30–60s, 35–40 Hz, 2–5 mm, increased progressively, vertical vibrations.
Sham: same exercise program on the vibration plate, but without vertical vibrations.
WBV vs. sham: No significant difference between groups for the TUG test (SMD = −0.38, 95% CI: −1.25, 0.48) and the Tinetti test (SMD = 0.00, 95% CI:−0.86, 0.86).
Bruyere et al. (9) 42 older adults, nursing home residents
WBV + Physical therapy: n = 22, 4 men, 18 women, mean age 84.5 years
Physical therapy: n = 20, 7 men, 13 women, mean age 78.9 years
3 times a week, 6 weeks, same PT 10 min
WBV + Physical therapy: n static exercise, 4 × 60 s/90 s, 10–26 Hz, 3–7 mm, vertical vibrations.
Physical therapy: PT only.
Lack of data post WBV. Groups were statistically different at baseline for the TUG test (p = 0.04).
The authors reported a significant decrease of 11.0 ± 8.6 s post WBV for the TUG test and an increase of 3.5 ± 2.1 points post WBV for the Tinetti gait score.
PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
Spielmanns et al. (71) 28 subjects with COPD stage II-IV.
WBVT group: n = 12, 8 men, 4 women, mean age 62.4 years.
Conventional training group (CTG): n = 16, 9 men, 7 women, mean age 68 years.
3 months, 2 sessions/week, same resistance, and endurance training.
WBVT group: Galileo vibration platform (No- votec Medical, Pforzheim, Germany), 3 × 20 squat repetitions, 24–26 Hz,3 mm, side-alternating vibration.
CTG: same of squat exercises but without WBVT.
WBV vs. control: no significant difference between groups for the 6MWT (SMD = 0.72, 95% CI:−0.05, 1.50).
Spielmanns et al. (65) 29 subjects with stable COPD in stage I to III
WB group: n = 14, 7 men, 7 women, mean age 69 years.
Calisthenics group: n = 14, 7 men, 7 women mean age 70 years.
3 months, twice per week.
WBV group: Galileo, Novotec Medical, Pforzheim, Germany, isometric squat position, 3 × 2 min/2 min, 6 −10 Hz, 4–6mm, side-alternating vibration.
Calisthenics group: relaxation, breathing retraining, calisthenics exercises.
WBV vs. Calistenic: no significant difference between groups for the 6MWT (SMD = 0.54, 95% CI:−0.23, 1.32).
Salhi et al. (61) 62 patients with COPD
WBV-group: n = 31, 21 men, 10 women, mean age 58 years.
Conventional resistance training (RT): n = 31, 23 men, 8 women, mean age 63 years.
12 weeks, 3 times a week, same pulmonary rehabilitation program.
WBV-group: FITVIBE, Gymna, Belgium, 8 upper and lower body exercises, 1–3 sets/exercise, 30–60s/n 27 Hz, 2 mm, vertical vibrations.
RT: lower and upper body exercises, 3 × 10repetitions
WBV vs. RT: no significant difference between groups for the 6MWT (SMD = −0.24, 95% CI: −0.79, 0.31)
Pleguezuelos et al. (57) 51 stable male patients with COPD
Whole Body Vibration Training Group: n = 26, mean age 68.4 years.
Control group: n = 25, mean age 71.3 years.
6 weeks, 3 sessions per week, regular prescribed medical treatment.
WBVTG: Gymnauni phy. Nv. Pasweg 6a 3740 Bilzen, Belgium, squatting position, 6 × 30s/60s, 35Hz and 2mm, vertical vibrations.
Control Group: general recommendations about physical activity and lifestyle.
WBV vs. control: no significant difference between groups for the 6MWT (SMD = 2.59, 95% CI 1.83, 3.35).
STROKE
Alp et al. (28) 21 post stroke patients
WBV: (n = 10), 10 men, 0 women, mean age 61.20 ± 11.043 years.
Control group: (n = 11) 9 men, 2 women, mean age 62.9 ± 8 years
4 weeks, 3 days a week, stretching and active range of motion exercises on the hemiplegic lower extremity for 15 min.
WBV: Compex Winplate by Uniphy Elektromedizin GmbH and CoKG, tiptoes, 3 × 10s/3–20 s, 5min, 40 Hz, 4 mm,n
Control group: same exercises, no vibration.
Lack of data post WBV. The groups were statistically different at baseline for the 10MWT (p < 0.001).
The authors reported a significant improvement of the 10MWT in favor of the WBV group (p < 0.001).
Choi et al. (72) 30 individuals who presented with a gait deviation after a first stroke (>6 months).
WBV-Treadmill Training (TT): n = 15, 8 men, 7 women, mean age 51.93 years.
TT group: n = 15, 11 men, 4 women, mean age 53.67 years.
6 weeks, 3 times a week, 20 min of TT for both groups.
WBV- TT: Galileo 2000, (Novotec, Germany, 2011), dynamic exercises, 6 × 45s/1min20-30 HZ, 3 mm, side- alternating vibration.
TT group: same exercises on the platform without vibration.
No significant difference between group for the Walking speed (SMD = 0.32, 95% CI: −0.40, 1.04) and stride length (SMD = 0.50, 95% CI: −0.23, 1.23).
Choi et al. (38) 22 individuals who were diagnosed with strokes at least 6 months prior to the study.
WBV group: n = 11, 8 males, 3 females, mean age 50.9 years.
Control group: n = 11, 7 males, 4 females, mean age 52.2 years.
4 weeks, 5 times per week.
WBV group: Galileo tilt table (Novotec Medical, Germany), squat posture, 10 min/session, 25 Hz, 5 mm,n
Control group: 30 min of Neuro-developmental treatment as the experimental group.
WBV vs. control group: no significant difference between group for the TUG test (SMD = −0.50, 95% CI : −1.35, 0.35).
Liao et al. (54) 84 individuals with hemispheric stroke persisting for more than 6 months before the time of enrolment
low-intensity WBV group (LWBV): n = 28, 20 men, 8 women, mean age 60.9 years
High-intensity WBV group (HWBV): n = 28, 18 men, 10 women, mean age 62.9 years
Control (CON): n = 28, 24 men, 4 women, mean age 59.8 years.
3 times a week, 30 sessions, same dynamic and static exercises, Gymna Fitvibe Medical System, Gymna Uniphy Pasweg, Bilzen, Belgium, synchronous vibrations.
LWBV: 20 Hz, 1 mm
HWBV: 30 Hz, 1 mm
Control (CON): standing on the same WBV platform turned off.
LWBV vs. control: no significant difference between group for the 6MWT (SMD = 0.05 95% CI:−0.47, 0.58) and for TUG test
(SMD = −0.10 95% CI: −0.62, 0.43).
HWBV vs. Control: no significant difference between group for the 6MWT (SMD = −0.03, 95% CI−0.55, 0.50) and for TUG test (SMD = −0.25, 95% CI: −0.77, 0.28).
Lau et al. (51) 82 chronic stroke patients.
WBV group: n = 41, 26 men, 15 women, mean age 57.3 years.
Control group: n = 41, 32 men, 9 women, mean age 57.4 years.
8 weeks, 3 times a week.
WBV: Jet-Vibe System (Danil SMC Co. Ltd., Seoul, South Korea), dynamic leg exercises, 6 exercises, 9–15 × 1,5-2, 5min/n, 20–30 Hz, 0.44–0.60 mm, vertical vibrations.
Control group: same exercises without vibration.
WBV vs. control: no significant improvement of the 6MWT
(SMD = −0.22 95% CI = −0.66, 0.21) and the 10MWT (SMD = 0.39 95% CI: −0.05, 0.83).
Brogårdh et al. (35) 31 individuals with chronic stroke.
WBV: n = 16, 13 men, 3 women, mean age 61.3 years.
Control group: n = 15, 12 men, 3 women, mean age 63.9 years.
6 weeks, 2 sessions/week.
WBV training: Xrsize, static position knee flexed,4–12 × 40–60s/1min, 25Hz, 3.75 mm, vertical vibrations.
Control group: placebo vibrating platform (25Hz,0.2 mm amplitude).
WBV vs. control group: groups were different at baseline for the TUG test and the 6MWT.
The authors reported significant improvements in both outcomes after WBV (p < 0.05)
van Nes Ilse et al. (67) 53 post-stoke patients
WBV group: n = 27, 16 males, 11 females, mean age of 59.7 years.
Exercise therapy on music group: n = 26, 14 males, 12 females, mean age of 62.6 years.
6 weeks, 5 days per week, physical therapy
WBV group: Galileo 900, Galileo 2000, Enschede, The Netherlands, squat position hips and knees slightly flexed, 4 × 45 s/60 s, 30 Hz, 3 mm, Side-alternating vibration.
Exercise therapy on music group: same standing position, exercises and relaxation.
WBV vs. exercise therapy on music group: no significant difference between groups (SMD = 0.00, 95% CI: −0.54, 0.54).
KNEE OSTEOARTHRITIS
Bokaeian et al. (33) 28 patients with knee osteoarthritis.
WBV + Strength Training (ST): n = 15, 0 men, mean age 51.8 years
Strength Training: n = 13, 2 men, 11 women, mean age 54 years.
8 weeks, 3 times a week, both groups received same PT and strengthening exercises protocol.
WBV + ST group: Fitvibe device (Italy), bent knees, 6–9 × 30–70 s/30–70 s, 25–30 HZ, 2 mm, progressively increased, vertical vibrations.
Strength Training: flexion and extension exercise of knee joint, 3 sets, 10 RM, progressive load.
Lack of data post WBV. The authors reported significant improvements for the 2MWT, 50FWT and TUGT in favor of the WBV + ST group (p = 0.009).
Wang et al. (68) 49 patients with knee osteoarthritis.
Whole Body Vibration Exercise + Quadriceps Resistance Exercise group: n = 49, 13 men, 36 women, mean age 61.2 years.
Quadriceps Resistance Exercise only group: n = 50, 15 men, 35, women, mean age 61.5 years.
24 weeks, 5 days/week.
WBV + QRE: My7TM model Personal Plate, Power Plate, USA, knees slightly flexed, 30 × 60 s/60 s, 35 Hz, 4–6 mm,n
Quadriceps Resistance Exercise: static and dynamic exercises.
WBV + QRE vs. QRT: significant improvement in favor of the WBV+QRE group for the TUG test (SMD = −3.11 95% CI: −3.71, −2.52) and the 6MWT (SMD = 1.68, 95% CI : 1.22, 2.14)
Simão et al. (63) 31 elderly subjects with knee osteoarthritis.
WBV group: n = 10, mean age 75 years.
Squat group: n = 10, mean age 73.4 years.
Control group: n = 11, mean age 71 years.
12 weeks, 3 times per week.
WBV group: FitVibe, squat exercise, 6–8 × 20–40 s/20–40 s, 35–40 HZ, 4 mm, vertical vibrations.
Squat group: 3s of isometric contraction.
Control group: without intervention. No change their lifestyle.
WBV vs. Control group: no significant difference between groups for the 6MWT (SMD = 0.56, 95% CI: −0.26, 1.37) and gait speed (SMD = 0.39, 95% CI−0.42, 1.20).
Avelar et al. (29) 21 elderly patients with knee osteoarthritis.
WBV group: n = 11, mean age 75 years.
Control group: n = 10, mean age 71 years.
12 weeks, 3 times per week.
WBV: FitVibe, GymnaUniphy NV, Bilzen, Belgium, squat training with WBV, 6–8 × 20–40 s/20–40 s, 35 Hz−40 Hz, 4 mm, n
Control: squat training without vibration.
WBV vs. control group: no significant difference between groups for the TUG test (SMD = 0.06, 95% CI: −0.80, 0.91). Significant improvement of the 6MWT in favor of the WBV group (SMD = 1.49, 95% CI: 0.49, 2.48).
POSTMENOPAUSAL WOMEN
Sucuoglu et al. (66) 42 postmenopausal women patients
WBV- Balance Coordination Exercise (BCE) group: n = 21, mean age 56 years.
BCE group: n = 26, mean age 58.76 years.
4 weeks, 10 sessions per week, identical BCE programs.
WBV-BCE group: Power Plate (Performance Health Systems UK Ltd, London, UK), 3 static positions, 2 × 30 s/60 s 30–35 Hz. 5 sessions per week, vertical vibrations.
BCE group: 20-min exercise sessions at home, twice per day.
Significant difference at baseline between groups for the TUG test.
The authors reported significant improvement compared with pretreatment values in both groups (p < 0.005).
Iwamoto et al. (48) 52 ambulatory postmenopausal women with osteoporosis.
WBV group: n = 26, mean age 72.4 years.
Control group: n = 26, mean age 76 years.
6 months, n
WBV group: Galileo machine (G- 900; Novotec, Pforzheim, Germany), bent knees, 4 min, 20 HZ, n, side to side alternating vibrations.
Control group: no exercise.
Lack of data post WBV.
The authors reported no significant difference between groups for the TUG test (p > 0.05) but significant improvement in favor of the WBV group for the 10MWT (p < 0.05).
Raimundo et al. (58) 27 postmenopausal women
WBV: n = 14, mean age 66 years
Walk based program: n = 13, mean age 66 years.
3 times a week, 8 months
WBV: Galileo 154 2000, Novotec GmbH, Pforzheim, Germany, static knees flexed at 120°, 3–6 × 1 min/1 min, 12,6 Hz, 6 mm, increased each week, side-alternating oscillations.
Walk based program: 2 × 25 min of walk, 70–75% HRmax
Lack of data post WBV. The authors reported a significant improvement of the 10MWT post WBV (p = 0.006).
MULTIPLE SCLEROSIS
Ebrahimi et al. (39) 34 multiple sclerosis patients with mild to moderate disability
WBV group: n = 17, 5 men, 12 women, mean age 37.06 years.
Control group: n = 17 4 men, 13 women, mean age 40.75 years.
10 weeks, 3 times a week.
WBV group: n, static positions, 15 × 30s−2 min/30 s−5 min, 2–20 Hz, 2 mm, n
Control group: continued their normal life
WBV vs. control group: no significant difference between groups for the TUG test (SMD = −0.47, 95% CI: −1.20, 0.26).
Significant improvement in favor of the WBV group for the 10MWT (SMD = −1.05, 95% CI: −1.82, −0.28) and the 6MWT (SMD = 1.22, 95% CI: 0.43, 2.01).
Broekmans et al. (34) 25 ambulatory community- based patients with multiple sclerosis.
WBV: n = 11, 7 men, 4 women, mean age 46.1 years
Control: n = 14, 11 men, 3 women, mean age 49.7 years
5 sessions per 2-week cycle, 20 weeks
WBV: Alpha Vibe® Nijverdal, The Netherlands, 2–5 static and dynamic leg squats and lunges, 1–3 × 30–60 s/30–120 s, 20–45 Hz, 2.5 mm, increased progressively, vertical vibrations.
Control: maintain their usual lifestyle
Groups were statistically different at baseline for the TUG test and 2MWT.
The authors reported no significant effects in both groups for the TUG test (p = 0.26) and the 2MWT (p = 0.25).
OTHER PATHOLOGIES IN ADULTS
In et al. (47) 28 patients who were diagnosed with incomplete cervical spinal injury
WBV group: n = 14, 9 men, 5 women, mean age 46.1 ± 9.8 years
Control group: n = 14, 10 men, 4 women, mean age 49.9 ± 9.3 years
8 weeks, 5 days a week, twice a day, conventional physical therapy
WBV group: TT2590X7, TurboSonic Co., South Korea, semi-squat with slight flexion (140°) at hips, knees and ankles, 4 × 45 s/1 min, 30Hz, 2–4 mm, vertical vibrations.
Control group: 16 min of placebo WBV and 30 min of physical therapy.
WBV vs. Control group: No significant difference between groups for the TUG test (SMD = −0.64, 95 CI: −1.40, 0.13) and the 10MWT (SMD = −0.23, 95% CI:-0.97, 0.52).
Gerhardt et al. (42) 22 adult patients with stable, symptomatic pulmonary arterial hypertension (PAH).
WBV group: n = 11, 7 men, 4 women, mean age 65.1 years.
Control group: n = 11, 6 men, 5 women, 46 years.
4 weeks, 16 sessions.
WBV group: Galileo MedM plat- form (Novotec Medical GmbH, Pforzheim, Germany), specific coordination exercises, n, 20 Hz, 20 mm, side alternating vibrations.
Control group: received WBV in a second phase.
Lack of data post WBV. The authors indicated that WBV was associated with a significant improvement of the 6MWD versus baseline of +38.6 ±6.6 m (p < 0.001)
Gloeckl et al. (43) 83 patients after lung transplantation.
WBVT group: n = 34, 16 men, 18 women, mean age 56 years.
Control group: n = 36, 22 men, 14 women, mean age 56 years.
4 weeks, 3 times per week, same pulmonary rehabilitation program.
WBVT group: GALILEO, Novotec Medical GmbH, Pforzheim, Germany, squat exercises, 4 × 2min/4min, 24–26 Hz, 6 mm, side alternating vibrations.
Control group: same squat training on the floor.
lack of data post WBV
The authors reported a between group difference of 28 m (95%CI: 3 m to 54 m, p = 0.029) significantly different in favor of WBVT.
Gaßner et al. (41) 17 participants diagnosed with idiopathic Parkinson's disease.
WBV group: n = 8, 6 men, 2 women, mean age 71.4 years.
Placebo group: n = 9, 7 men, 2 women, mean age 68.2 years.
5 weeks, 2–3 times a week.
WBV group: SRT Zeptor Medical plus noise, static position, 5 × 60 s/60 s, knees slightly bents, 6 Hz, 3 mm, n
Placebo group: stood on the vibration platform in the same basic position.
WBV vs. placebo group: no significant difference between group for the TUG test (SMD = −0.37, 95% CI: −1.34, 0.59), velocity (SMD = −0.21, 95% CI: −1.17, 0.74) and step length (SMD = 0.14, 95% CI: −0.81, 1.09).
Johnson et al. (49) 16 individuals, 3–6 weeks post total knee arthroplasty
WBV: n = 8, 6 men, 2 women, mean age 67 years
Traditional Progressive Resistance Exercise (TPRT): n = 8, 4 men, 4 women, mean age 68.5 years
3 session a week, 4 weeks
WBV: Power Plate, Badhoevendorp, The Nertherlands, static and dynamic exercises, 4–6 exercises/session, 1–3 set/exercise, 30–60 s/n,35 Hz, 2–5 mm, n
TPRE: 1–3 SET of 10 REP for strengthening exercises for lower limbs, exercises were progressed once the patient could complete the exercise
WBV vs. TRPE: no significant difference for the TUG test (SMD = −0.59, 95% CI: −1.59, 0.42).
Ahlborg et al. (27) 14 persons with cerebral palsy, spastic diplegia
WBV: n = 7, 4 men, 3 women, mean age 32 years
Resistance training: n = 7, 4 men, 3 women, mean age 30 years
Three times weekly, 8 weeks, same warming up and stretching
WBV: NEMES-LSC (Nemesis BV, Hengelo, The Netherlands), standing position, hips and knees in 50° of flexion, 1–4 × 30–110 s/15–120 s, increased progressively, 11 levels of intensity, 25–40 Hz, 7/10 on the Borg Scale, n
Resistance training: leg press, 3 SET of 10–15 REP, progressive load.
WBV vs. RT: no significant difference between groups for the TUG test (SMD = 0.28, 95% CI: −0.77, 1.34).
OTHER PATHOLOGIES IN CHILDREN
Högler et al. (46) 24 children (5–16 years) with clinically mild to moderate osteogenesis imperfecta.
WBV training: n = 12, 6 men, 6 women, mean age 9.38 years.
Control group: n = 12, 6 men, 6 women, mean age 6.49 years.
5 months, twice-daily, home use
WBV training: Galileo MTM, Novotec Medical, Pforzheim, Germany), static and dynamic exercises, 3 × 3 min/3 min, 20–25 Hz, side alternating vibrations.
Control group: continued to receive regular care.
Lack of data post WBV. The authors reported no significant difference between groups for the 6MWT (p = 0.278)
Cheng et al. (37) 16 children with cerebral palsy, 8 boys and 8 girls, mean age 9.2 years.
WBV group: n = 8, n
Control group: n = 8, n
8-week WMV intervention followed by an 8-week control condition, with a 4-week rest (crossover study).
WBV: AV-001A, Body Green, Taipei, Taiwan, static position, 10 min, 20 Hz, 2 mm, vertical vibrations.
Control: same procedure with the machine turned off.
Lack of data post WBV. The authors reported a significant difference between the treatment and control condition for the 6MWT (p = 0.005).
Lee and Chon. (52) 30 patients with either the spastic diplegia or quadriplegia forms of cerebral palsy
WBV group: n = 15, 6 men, 9 women, mean age 10 years.
Control group: n = 15, 9 men, 6 women, mean age 9.66.
8 weeks, 3 days per week, conventional PT.
WBV: Galileo system (Novotec Medical GmbH, Pforzheim, Germany), squat position, 6 × 3 min/3 min, 5–25 Hz, 1–9 mm, side alternating vibrations.
Control group: conventional physical therapy training.
WBV vs. control group:
Significant improvement in favor of the WBV group for the gait speed (SMD = 1.41, 95% CI: 0.60, 2.22) and stride length (SMD = 0.91, 95% CI: 0.15, 1.67)
Ruck et al. (60) 20 children with cerebral palsy
WBV: n = 10, 8 boys, 2 girls mean age 8.3 years
Control: n = 10, 6 boys, 4 girls, mean age 8.1 years
Physiotherapy according to the established school program, 6 months, 5 days per week
WBV: Vibraflex Home Edition II®, Orthometrix Inc, White Plains, NY. Outside of North America, Galileo Basic, knees and hips flexed 10–45°, dynamic exercises, 3 × 3 min/3 min, 12–18 Hz, 2–6 mm, side to side alternating vertical vibrations.
Control: Physiotherapy only
Lack of data post WBV. The authors reported a significant improvement of the 10MWT in favor of the WBV (p = 0.03).

WBV, Whole body vibration; TUG, Timed up and go test; 6MWT, 6-minute walk test; 2MWT, 2-minute walk test; 50FWT, 50-feet walk test; 10MWT, 10-meter walk test.