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. 2019 Jun 26;10:424. doi: 10.3389/fendo.2019.00424

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Copyright © 2019 Milanova, Kalsbeek, Wang, Korpel, Stenvers, Wolff, de Goede, Heijboer, Fliers, la Fleur, Kalsbeek and Yi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglial mitochondria signaling during DIO. Relative gene expression of mitochondria bioenergetics genes Cox4 (A), Atp5b (B), and Pdk4 (C), as well as mitochondria dynamics gene Fis1 (D), Drp1 (E), Mfn2 (F), and Opa1 (G) in HFD-fed rats (red) compared to Chow-fed controls (black) evaluated at six time points, starting at ZT2. Data are presented as means ± SEM. Statistical significance was determined using Two-way ANOVA effect for Interaction, Diet, and Time (ZT); Student t-test is used for diet effect within a separate time point (*p < 0.05; **p < 0.01). Scale (bottom right) represents light (ZT0-12) and dark (ZT12-24) phase.