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. 2019 Jun 20;10:564. doi: 10.3389/fgene.2019.00564

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Copyright © 2019 Zhu, Pan, Yang, Meng, Jiang, Tao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CircNFIB is decreased in cardiac fibrosis. (A) CircNFIB is decreased in ventricle samples from 21 days post-myocardial infarction mice (n = 5:6). (B) circNFIB is decreased in primary adult cardiac fibroblasts treated by TGF-β (n = 5:6). (C) Results of sequencing of divergent PCR products generated from circNFIB confirmed the head-to-tail junction point. (D) The transfection efficacy of circNFIB plasmid is confirmed by qRT-PCR (n = 6). (E) The transfection efficacy of circNFIB siRNA is confirmed by qRT-PCR (n = 4). ^*p < 0.05, ^∗∗p < 0.01 versus controls.