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. 2019 Jun 21;10:1406. doi: 10.3389/fimmu.2019.01406

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Copyright © 2019 Mándi, Endrész, Mosolygó, Burián, Lantos, Fülöp, Szatmári, Lőrinczi, Balog and Vécsei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between the TSG-6 expression and TNF-α production by U-937 cells infected with C. pneumoniae at a MOI 5 in the presence of KYNA or the analogs. U-937 cells were pretreated for 30 min with KYNA or KYNA analogs at a concentration of 500 μM, and thereafter incubated for 24 h with 5 MOI of Chlamydia pneumoniae. The TNF-α levels in the supernatants were determined with ELISA assay, and the TSG-6 expression by RT qPCR reactions. The significance of correlation was calculated by correlation analysis with the Graph-Pad Prism 5 statistical program. Symbols and numbers represent the data obtained with KYNA or KYNA analogs. Cpn: incubation only with Chlamydia pneumoniae without compounds. The correlation coefficient, r value is-0.891, the p-value = 0.0072, the 95% confidence interval is −0.9838 to −0,4174.