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. 2019 Jun 21;10:614. doi: 10.3389/fphar.2019.00614

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Copyright © 2019 Kwan, Huang, Leung, Dong and Tsim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DBT regulates mitochondrial biogenesis-related genes. The expression levels of (upper panel) mitochondrial biogenesis related gene (PGC-1α, NRF1, TFAM) and (lower panel) mitochondrial DNA replication related gene (PLOG, TOP1MT, TWINKLE) were quantified by RT-PCR, following treatment of H9C2 cells with DBT, ASR, AR, and ASR+AR at 0.1 mg/ml for 24 h. Data are expressed as the ratio to the background (no treatment). Values are in mean ± SD, with n = 3. Statistical comparison was made of the sample with the background, *p < 0.1, **p< 0.01, and ***p < 0.001.