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. 2016 Oct 19;2016(10):CD005088. doi: 10.1002/14651858.CD005088.pub4

Comparison 2. IV bisphosphonates versus placebo or no treatment.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Number of participants with at least one fracture 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 At 1 year 2 110 Risk Ratio (M‐H, Fixed, 95% CI) 0.56 [0.30, 1.06]
2 Incidence of lower extremity fractures 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
2.1 At 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 Incidence of upper extremity fractures 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.1 At 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 Mean % change (from baseline) in spine BMD (DEXA) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
4.1 At 6 months 2 125 Mean Difference (IV, Random, 95% CI) 9.96 [‐2.51, 22.43]
4.2 At 12 months 2 125 Mean Difference (IV, Random, 95% CI) 14.68 [‐6.08, 35.45]
5 Mean % change (z score) in spine BMD (DEXA) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.1 At 6 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 At 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Mean % change in total hip BMD (DEXA) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
6.1 06 months 2 108 Mean Difference (IV, Random, 95% CI) 6.16 [‐3.57, 15.90]
6.2 12 months 2 108 Mean Difference (IV, Random, 95% CI) 11.27 [‐3.69, 26.22]
7 Change in vertical growth (cm/year) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
7.1 At 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Bone pain scores 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
8.1 At 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Muscle strength 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
9.1 At 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
10 BAMF (10‐point gross motor assessment) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
10.1 At 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]