Bishop 2013.

Methods	Parallel, double‐blind RCT.
Participants	Children and adolescents with a diagnosis of OI (types not stated) with a history of at least 1 non‐traumatic/low‐impact fracture and BMD z score of ‐1.0 or less for total body or LS OR a real BMD z score of ‐2.0 or less regardless of fracture history. Those considered ineligible weighed less than 10kg, had cancer or untreated rickets, had low vitamin D or prior treatments which might have affected the results or disease severe enough they would have normally been given treatment anyway. 4 ‐ 15 years 71 females 72 males
Interventions	94 risedronate 49 placebo (10 kg ‐ 30 kg) 2.5 mg daily (> 30 kg) 5 mg daily
Outcomes	Primary: % change from baseline lumbar spine BMD Secondary: % change from baseline in total body BMD at Month 12 % change from baseline in lumbar spine BMC at month 12 % change from baseline in total body BMC at month 12 Lumbar spine z score ‐ % change from baseline to month 12 Total body z score ‐ % change from baseline to month 12 % change from baseline in lumbar spine bone area at month 12 % change from baseline in total body bone area month 12 New morphometric vertebral fracture at month 12 Categorization by number of new morphometric vertebral fracture at month 12 Probability of fracture in 12 months Number of clinical fractures, month 12 Serum BAP ‐ % change from baseline to month 12 Urine NTX/Cr ‐ % change from baseline at month 12 Wong‐Baker FACES Pain Rating Scale ‐ change from baseline to month 12 Bone Age (years), change from baseline to month 12 Annualized growth velocity ‐ change from baseline to month 12
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomized in a 2:1 ratio by a telephone based interactive voice response system
Allocation concealment (selection bias)	Low risk	Telephone based interactive voice response system
Blinding (performance bias and detection bias) All outcomes	Low risk	The trial treatment was masked from participants, investigators, and trial centre personnel during the first year.
Incomplete outcome data (attrition bias) All outcomes	Low risk	7 participants discontinued in the intervention arm and reasons were provided. An ITT analysis was undertaken.
Selective reporting (reporting bias)	Low risk	All outcomes are reported.
Other bias	Low risk	None