Senthilnathan 2008.

Methods	Single‐centre, parallel, double blinded, RCT.
Participants	12 randomised, 6 in each group. Number who received treatment and were analysed Low dose = 6 High dose = 4 Infants with OI who had long bone fractures with consequent deformity at birth or within the first 3 months of life, and/or multiple crush fractured vertebrae 7 males and 5 females under one year of age.
Interventions	6 or 12 mg/kg/year of pamidronate by IV infusion.
Outcomes	Change in BMD as assessed by DEXA, Change in biochemical markers of bone and mineral metabolism (e.g., bone alkaline phosphatase measurements), growth.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised.
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Carers and participants blinded and outcome assessors.
Incomplete outcome data (attrition bias) All outcomes	Low risk	One infant died from pneumonia 3 weeks after receiving the first infusion and one infant was withdrawn due to non attendance for scheduled infusions. Both were in the 12 mg/kg group (high dose).
Selective reporting (reporting bias)	Low risk	Outcomes reported.
Other bias	Unclear risk	Problems with accrual.