TABLE 1.
Human m6A proteins.
| Protein | Function | References |
| Writers | ||
| METTL3 | Installs m6A residues in mRNAs and lncRNAs | Liu et al.,2014 |
| METTL14 | Cooperates with METTL3 in m6A deposition | Liu et al.,2014 |
| METTL16 | Installs m6A in U6 snRNA and few mRNAs and lncRNAs | Pendleton et al., 2017; Warda et al.,2017 |
| Erasers | ||
| FTO | Remove m6A and m6Am from mRNA, and m1A from tRNA | Jia et al.,2011 |
| ALKBH5 | Remove m6A from mRNA | Zheng et al.,2013 |
| Regulators | ||
| WTAP | Regulates m6A installation by the METTL3/METTL14 complex | Ping et al.,2014 |
| VIRMA | Regulates m6A installation by the METTL3/METTL14 complex | Knuckles et al., 2018; Yue et al.,2018 |
| CBLL1 | Regulates m6A installation by the METTL3/METTL14 complex | Wen et al., 2018; Yue et al.,2018 |
| RBM15 | Regulates m6A installation by the METTL3/METTL14 complex | Knuckles et al.,2018 |
| ZC3H13 | Regulates m6A installation by theMETTL3/METTL14 complex | Knuckles et al., 2018; Wen et al.,2018 |
| Direct readers | ||
| ABCF1 | Stimulates cap-independent translation | Coots et al.,2017 |
| eIF3 | Stimulates cap-independent translation | Meyer et al.,2015 |
| HNRNPA2B1 | Stimulates microRNA processing | Alarcón et al.,2015a |
| IGF2BPs | Increase mRNA stability | Huang et al.,2018 |
| YTHDC1 | Stimulates splicing and mRNA export | Xiao et al., 2016; Roundtree et al.,2017 |
| YTHDC2 | Stimulates mRNA decay and translation | Hsu et al., 2017; Wojtas et al.,2017 |
| YTHDF1 | Stimulates translation | Wang et al.,2015 |
| YTHDF2 | Stimulates mRNA decay | Wang X. et al.,2014 |
| YTHDF3 | Stimulates mRNA decay and translation | Li et al., 2017; Shi et al.,2017 |
| Indirect readers | ||
| FMR1 | Inhibits translation | Edupuganti et al.,2017 |
| HNRNPC | Regulates splicing | Liu et al.,2015 |
| m6A repelled | ||
| ELAVL1 | Increases mRNA stability | Wang X. et al.,2014 |
| G3BPs | Increases mRNA stability | Edupuganti et al.,2017 |