Writers |
|
|
METTL3 |
Installs m6A residues in mRNAs and lncRNAs |
Liu et al.,2014 |
METTL14 |
Cooperates with METTL3 in m6A deposition |
Liu et al.,2014 |
METTL16 |
Installs m6A in U6 snRNA and few mRNAs and lncRNAs |
Pendleton et al., 2017; Warda et al.,2017
|
Erasers |
|
|
FTO |
Remove m6A and m6Am from mRNA, and m1A from tRNA |
Jia et al.,2011 |
ALKBH5 |
Remove m6A from mRNA |
Zheng et al.,2013 |
Regulators |
|
|
WTAP |
Regulates m6A installation by the METTL3/METTL14 complex |
Ping et al.,2014 |
VIRMA |
Regulates m6A installation by the METTL3/METTL14 complex |
Knuckles et al., 2018; Yue et al.,2018
|
CBLL1 |
Regulates m6A installation by the METTL3/METTL14 complex |
Wen et al., 2018; Yue et al.,2018
|
RBM15 |
Regulates m6A installation by the METTL3/METTL14 complex |
Knuckles et al.,2018 |
ZC3H13 |
Regulates m6A installation by theMETTL3/METTL14 complex |
Knuckles et al., 2018; Wen et al.,2018
|
Direct readers |
|
|
ABCF1 |
Stimulates cap-independent translation |
Coots et al.,2017 |
eIF3 |
Stimulates cap-independent translation |
Meyer et al.,2015 |
HNRNPA2B1 |
Stimulates microRNA processing |
Alarcón et al.,2015a |
IGF2BPs |
Increase mRNA stability |
Huang et al.,2018 |
YTHDC1 |
Stimulates splicing and mRNA export |
Xiao et al., 2016; Roundtree et al.,2017
|
YTHDC2 |
Stimulates mRNA decay and translation |
Hsu et al., 2017; Wojtas et al.,2017
|
YTHDF1 |
Stimulates translation |
Wang et al.,2015 |
YTHDF2 |
Stimulates mRNA decay |
Wang X. et al.,2014 |
YTHDF3 |
Stimulates mRNA decay and translation |
Li et al., 2017; Shi et al.,2017
|
Indirect readers |
|
|
FMR1 |
Inhibits translation |
Edupuganti et al.,2017 |
HNRNPC |
Regulates splicing |
Liu et al.,2015 |
m6A repelled |
|
|
ELAVL1 |
Increases mRNA stability |
Wang X. et al.,2014 |
G3BPs |
Increases mRNA stability |
Edupuganti et al.,2017 |