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. 2019 Jun 28;12:5003–5012. doi: 10.2147/OTT.S207560

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© 2019 Shen et al.

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ARHGAP4 up-regulation inhibited mTOR and HIF-1α signaling pathways in BxPC-3 and SW1990 cells. (A) GSEA demonstrated the genes of mTOR and HIF signaling pathways were more correlated with patients with ARHGAP4 low vs ARHGAP4 high. NES, normalized enrichment score. BxPC-3 and SW1990 cells were transduced with pLVX-Puro-ARHGAP4 lentivirus or blank lentivirus (vector), and the p-mTOR, mTOR, HIF-1α, and PKM2 expressions were measured by Western blot (B, D, E, G) and Real-time PCR (C, F). ***P<0.001 compared with vector.