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. 2019 Jun 28;12:5003–5012. doi: 10.2147/OTT.S207560

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© 2019 Shen et al.

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ARHGAP4 downregulation induced cell viability, glucose uptake, and lactate release through mTOR and HIF-1α signaling pathways in PANC-1 cells. PANC-1 cells were transfected with three siRNAs targeting human ARHGAP4 or scramble siRNA (siNC), and the ARHGAP4 expression was measured by Western blot (A). Cell viability (B), glucose uptake (C, D), lactic acid production (E) and protein levels of p-mTOR, mTOR, HIF-1α, and PKM2 (F–H) in PANC-1 cells with siRNA-1 or siNC transfection were determined in the presence of either mTOR inhibitor (Rapamycin, 10 nM) or HIF-1α inhibitor (YC-1, 20 μM). ***P<0.001 compared with siNC. ###P<0.001 compared with siARHGAP4.