Figure 2. Dose-response effect of CDDP (5, 10 and 15 μM) in combination with PJ34 (5 and 10 μM) on cell vaibility and IC₅₀ value of CDDP at different time points.

(A–D), HeLa cells were treated with different doses of CDDP in combination with 5 μM (A) or 10 μM (B) of PJ34. SiHa cells were treated with different doses of CDDP in combination with 5 μM (C) or 10 μM (D) of PJ34. (E–I), HeLa cells were treated with different doses of CDDP in combination with 5 μM (E) or 10 μM (F) of PJ34. SiHa cells were treated with different doses of CDDP in combination with 5 μM (G) or 10 μM (H) of PJ34. HeLa and SiHa cells were treated with 10 nM of PARP-1 siRNA in combination with various doses of CDDP (I). Table representing fold change in the IC₅₀ value of CDDP upon combined treatment with PARP-1 inhibitor and CDDP vs. CDDP alone in HeLa and SiHa cells (J). Error bars represent mean ± SD (n ≥ 3 independent experiments). IC₅₀ values for combined treatment with PJ34 and CDDP at different time points along with their p value is mentioned in the table. ^* p < 0.05; ^** p<0.01; ^*** p<0.001.