Table 4. A cluster of mutations in the fusion related external domain at the N terminus of the F1 part of the fusion protein of PP1.
N terminus of F1 103 FAGIAIGIAAALGVATAAQVT* 123.
| Position | Mut | Effect | P1 geno | P1 anti | P6c geno | P6c anti |
|---|---|---|---|---|---|---|
| 4869 | U>G | F108 I>M | 3/385 | 4/58 | 1/176 | 3/28 |
| 4873 | A>U | F110 I>F | 6/380 | 3/59 | 3/170 | 0/32 |
| 4881 | A>C | F113 A syn | 3/365 | 4/59 | 3/170 | 3/35 |
| 4884 | C>G | F114 L syn | 10/367 | 4/64 | 9/169 | 0/35 |
| 4888 | G>U | F116 V>F | 5/360 | 2/66 | 4/169 | 1/36 |
| 4892 | C>A | F117 A>E | 12/335 | 2/67 | 6/161 | 0/38 |
| 4894 | A>C | F118 T>P | 19/328 | 9/65 | 13/159 | 4/38 |
| 4898 | C>A | F119 A>E | 8/326 | 0/66 | 1/161 | 0/39 |
| 4901 | C>A | F120 A>E | 12/330 | 1/66 | 5/161 | 1/39 |
| 4903 | C>A | F121 Q>K | 22/329 | 7/66 | 11/159 | 1/38 |
| 4907 | U>A | F122 V>E | 20/327 | 1/69 | 11/156 | 2/42 |
| total | 120/3832 | 37/705 | 67/1811 | 14/400 | ||
| frequency | 3.1% | 5.2% | 3.7% | 3.5% |
* In large capitals the residues of the fusion related external domain that are affected by the mutations and in bold those that are changed as a result of a non-synonymous mutation.