Table 2.
Details of the PRP treatment protocols and the controls
| Author | Date | PRP |
HA |
||||
|---|---|---|---|---|---|---|---|
| Category | Activation | Injection Dose, Times, and Intervals | Fresh/Frozen | Type | Injection Dose, Times, and Intervals | ||
| Paterson et al. [28] | 2016 | PA-PRP | Ultraviolet light | 3 mL, 3 times, weekly | Fresh | Hylan G-F 20 | 3 mL, 3 times, weekly |
| Li et al. [29] | 2011 | PRP | Calcium chloride | 3.5 mL, 3 times, 3 weeks | Fresh | Sofast | 2 mL, 3 times, 3 weeks |
| Cerza et al. [30] | 2012 | ACP | NA | 5.5 mL, 4 times, weekly | Fresh | Hyalgan | 20 mg, 4 times, weekly |
| Cole et al. [31] | 2017 | PRP | NA | 4 mL, 3 times, weekly | Fresh | Hylan G-F 20 | 16 mg, 3 times, weekly |
| Duymus et al. [32] | 2016 | PRP | NO | 5 mL, 2 times, monthly | Fresh | Ostenil Plus | 40 mg, 1 time, monthly |
| Filardo et al. [33] | 2015 | PRP | 10% calcium chloride | 5 mL, 3 times, weekly | Fresh | Hyalubrix | 30 mg, 3 times, weekly |
| Gormeli et al. [34] | 2015 | PRP | 1 mL of calcium chloride | 5 mL, 3 times, weekly | 1 fresh/2 frozen | Orthovisc | 2 mL, 3 times, weekly |
| Montanez-Heredia et al. [35] | 2016 | PRP | NA | NA, 3 times, 15 days | Frozen | Adant | NA, 3 times, 15 days |
| Raeissadat et al. [36] | 2015 | LR-PRP | NO | 4–6 mL, 2 times, 4 weeks | Fresh | Hyalgan | 20 mg, 3 times, weekly |
| Sanchez et al. [37] | 2012 | PRGF | 400 uL of calcium chloride | 8 mL, 3 times, weekly | Fresh | Euflexxa | NA, 3 times, weekly |
| Vaquerizo et al. [21] | 2013 | PRGF | 400 uL of calcium chloride | 8 mL, 3 times, weekly | Fresh | Durolane | NA, 1 time |
| Raeissadat et al. [38] | 2017 | PRGF | 1.5 mL of Rooyagen | 5 mL, 2 times, 3 weeks | Fresh | Hyalgan | 20 mg, 3 times, weekly |
| Su et al. [2] | 2018 | LR-PRP | Calcium chloride | 6 mL, 2 times, 14 days | Fresh | Freda | 2 mL, 5 times, weekly |
| Filardo et al. [22] | 2012 | PRP | NA | 5 mL, 3 times, weekly | Frozen | Hyalubrix | NA, 3 times, weekly |
| Louis et al. [39] | 2018 | PRP | Calcium chloride | 3 mL, 1 time | Fresh | Durolane | 3 mL, 1 time |
ACP = autologous conditioned plasma; HA = hyaluronic acid; LP-PRP = leukocyte-poor platelet-rich PRP; LR-PRP = leukocyte-rich platelet-rich PRP; NA = data not available; NO = No Activation; PA-PRP = photo-activation and platelet-rich plasma; PRGF = plasma rich in growth factors; PRP = platelet-rich plasma.