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. 2019 Jun 24;15(6):e1008244. doi: 10.1371/journal.pgen.1008244

Fig 6. Osteosclerosis of FF mice is not caused by the metabolic syndrome.

Fig 6

A) Femoral trabecular bone volume of control and FF mice maintained for 3 months at 23 C (RT) or 30 C. B) Serum insulin of FF mice with or without metformin treatment. Control mice serve as normal control. C) Glucose tolerance test of 2 month old FF and control littermates. D) Insulin tolerance test of 2 month old FF and control littermates. E) Glucose tolerance test of FF and control mice after 3 months treatment with or without metformin. F) μCT quantitative analysis of distal femurs of FF and control mice following 3 months with or without metformin. Data are presented as mean ± SD. *p<0.05; **p<0.01; ***p<0.001; NS: no significance as determined by 1 way ANOVA (B) and 2 way ANOVA with Holm-Sidak's post hoc analysis for multiple comparisons test (A,C,D,E,F).