Table 1. Demographic and clinical profiles of cohorts.
| Training | Validation | |||
|---|---|---|---|---|
| Cases (N = 35,866) |
Controls (N = 179,330) |
Cases (N = 9,079) |
Controls (N = 581,316) |
|
| Age, years, mean (SD) | 77.24 (6.95) | 77.24 (6.95) | 77.19 (6.99) | 58.71 (11.35) |
| Gender, male, N (%) | 13,794 (38.46) | 68,970 (38.46) | 3,432 (37.80) | 267,801 (46.07) |
| Diagnosis Codes, N(%) | ||||
| HYPERTENSION (401.9) | 21,580 (60.17) | 98,672 (55.02) | 5,419 (59.69) | 187,144 (32.19) |
| HYPERLIPIDEMIA (272.4) | 17,229 (48.04) | 82,314 (45.90) | 4,357 (47.99) | 191,833 (33.00) |
| HYPERCHOLESTEROLEMIA (272.0) | 10,768 (30.02) | 58,244 (32.48) | 2,814 (30.99) | 116,730 (20.08) |
| PAIN IN SOFT TISSUES OF LIMB (729.5) | 10,112 (28.19) | 42,702 (23.81) | 2,566 (28.26) | 91,039 (15.66) |
| OTHER MALAISE AND FATIGUE (780.79) | 9,540 (26.60) | 34,465 (19.22) | 2,403 (26.47) | 87,362 (15.03) |
| Procedure Codes N (%) | ||||
| RADIOLOGIC EXAMINATION, CHEST (71020) | 13,915 (38.80) | 61,303 (34.18) | 3,518 (38.75) | 14,3310 (24.65) |
| DIAGNOSTIC RADIOGRAPHIC PROC (76499) | 12,759 (35.57) | 64,037 (35.71) | 3,235 (35.63) | 205,253 (35.31) |
| SCREENING MAMMOGRAPHY (77052) | 8,884 (24.77) | 51,472 (28.70) | 2,287 (25.19) | 171,086 (29.43) |
| BONE DENSITY STUDY (77080) | 6,815 (19.00) | 38,011 (21.20) | 1,746 (19.23) | 85,077 (14.64) |
| CT, HEAD OR BRAIN (70450) | 6,266 (17.47) | 18,047 (10.06) | 1,609 (17.72) | 28,423 (4.89) |
| Drug Codes N (%) | ||||
| HYDROCODONE BIT/ACETAMINOPHEN | 4,198 (11.70) | 12,686 (7.07) | 1,046 (11.52) | 72,548 (12.48) |
| SIMVASTATIN | 3,548 (9.89) | 12,584 (7.02) | 968 (10.66) | 37,149 (6.39) |
| AZITHROMYCIN | 3,221 (8.98) | 12,561 (7.00) | 823 (9.06) | 69,553 (11.96) |
| LISINOPRIL | 3,211 (8.95) | 10,926 (6.09) | 824 (9.08) | 31,572 (5.43) |
| LEVOTHYROXINE SODIUM | 2,663 (7.42) | 9,623 (5.37) | 682 (7.51) | 29,602 (5.09) |