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. 2019 Jul 5;14(7):e0219446. doi: 10.1371/journal.pone.0219446

Fig 4. Analysis of trinucleotide repeats by long-read SMRT sequencing for RE+/FECD+.

Fig 4

a. Repeat count histogram for representative RE+/FECD+ sample 37. Only the smaller allele (peak at 19 repeats) is detected by this software at this depth of coverage. b. CAG repeat length versus ZMWs for sample 37. c. HTT repeat analysis plot of sample 37. Blue and red areas depict AGG and CAG repeats as described in Fig 1C. d. Southern blot of 37 (lane 2), showing repeat expansion fragments up to 8 kb. Lane 1 is another RE+/FECD+ sample. Lane L contains radioactive size markers as indicated.